菏泽医学专科学校学报
菏澤醫學專科學校學報
하택의학전과학교학보
JOURNAL OF HEZE MEDICAL COLLEGE
2015年
3期
24-27
,共4页
过敏性紫癜性肾炎%肾活检%临床分析
過敏性紫癜性腎炎%腎活檢%臨床分析
과민성자전성신염%신활검%림상분석
Nephritis of Schonlein-Henoch purpura%Renal biopsy%Clinicopathologic
目的 探讨儿童过敏性紫癜性肾炎患者的临床表现、病理特点及其相关性.方法 回顾性总结分析经临床及肾活检确诊为过敏性紫癜性肾炎的87例患儿的临床表现及病理特点.结果 紫癜性肾炎87例,平均年龄为8.63岁.其临床表现多样化,血尿和蛋白尿43例,占49.4%;其次为肾病综合征型22例,占25.3%;肾脏病理分级以Ⅲ和Ⅱ级最为常见,分别为41例(47.1%)、39例(44.8%).免疫病理方面IgA者者41例,占47.1%,者30例,占34.5%.单纯IgA阳性者12例,占13.8%;合并IgG沉积者5例,占5.7%;合并IgM的沉积者39例,占44.8%;合并补体C3沉积者70例,占80.5%.结论 紫癜性肾炎在儿童发病率高,危害性较大.其临床表现及病理改变多种多样,临床疑似紫癜性肾炎患者建议肾活检以明确诊断.
目的 探討兒童過敏性紫癜性腎炎患者的臨床錶現、病理特點及其相關性.方法 迴顧性總結分析經臨床及腎活檢確診為過敏性紫癜性腎炎的87例患兒的臨床錶現及病理特點.結果 紫癜性腎炎87例,平均年齡為8.63歲.其臨床錶現多樣化,血尿和蛋白尿43例,佔49.4%;其次為腎病綜閤徵型22例,佔25.3%;腎髒病理分級以Ⅲ和Ⅱ級最為常見,分彆為41例(47.1%)、39例(44.8%).免疫病理方麵IgA者者41例,佔47.1%,者30例,佔34.5%.單純IgA暘性者12例,佔13.8%;閤併IgG沉積者5例,佔5.7%;閤併IgM的沉積者39例,佔44.8%;閤併補體C3沉積者70例,佔80.5%.結論 紫癜性腎炎在兒童髮病率高,危害性較大.其臨床錶現及病理改變多種多樣,臨床疑似紫癜性腎炎患者建議腎活檢以明確診斷.
목적 탐토인동과민성자전성신염환자적림상표현、병리특점급기상관성.방법 회고성총결분석경림상급신활검학진위과민성자전성신염적87례환인적림상표현급병리특점.결과 자전성신염87례,평균년령위8.63세.기림상표현다양화,혈뇨화단백뇨43례,점49.4%;기차위신병종합정형22례,점25.3%;신장병리분급이Ⅲ화Ⅱ급최위상견,분별위41례(47.1%)、39례(44.8%).면역병리방면IgA자자41례,점47.1%,자30례,점34.5%.단순IgA양성자12례,점13.8%;합병IgG침적자5례,점5.7%;합병IgM적침적자39례,점44.8%;합병보체C3침적자70례,점80.5%.결론 자전성신염재인동발병솔고,위해성교대.기림상표현급병리개변다충다양,림상의사자전성신염환자건의신활검이명학진단.
Objective To study the clinical manifestation, pathological features and their correlation in children patients with Henoch-Sch?nlein purpura nephritis. Methods The clinicopathological data of 87 biopsy-proven cases of HSPN from Jan. 2008 to Dec. 2013 were retrospectively analyzed. Results The average age of the patients was 8.63 ± 2.71 years old. Clinically, hematuria and proteinuria was the most common clinical type (43,49.4%), followed by nephrit-ic syndrome(22,25.3%). The majority of pathological changes of HSPN were gradeⅢwith 41 cases(47.1%) andⅡwith 39 cases(44.8%). The IgA fluorescence intensity ofwas the most common seen in HSPN, accounting for 47.1%andwas the next in order, accounting for 34.5%.Immunopathological results showed that merely staining of IgA in mesangial area was in 12 patients, accounting for 13.8%. Staining of IgA combined with IgG was in 5.7%of 87 patients. Staining of IgA combined with IgM was in 44.8%. 70 patients had C3 deposit, accounting for 80.5%. Conclusion HSPN has high morbidity rate in children and has diverse clinical manifestation and pathological changes. Early renal biopsy should be performed in the patients who are doubted to be HSPN to clarify the diagnosis and guide treatment.
