实用妇科内分泌电子杂志
實用婦科內分泌電子雜誌
실용부과내분비전자잡지
Journal of Practical Gynecologic Endocrinology
2015年
5期
1-2,4
,共3页
子宫内膜癌%子宫内膜不典型增生%正常子宫内膜%Maspin%P53%免疫组织化学
子宮內膜癌%子宮內膜不典型增生%正常子宮內膜%Maspin%P53%免疫組織化學
자궁내막암%자궁내막불전형증생%정상자궁내막%Maspin%P53%면역조직화학
Endometrial carcinoma%Atypical hyperplasia%Normal endometrium%Maspin%P53%Immune tissue chemistry
目的 通过检测子宫内膜癌,子宫内膜不典型增生,正常子宫内膜中的丝氨酸蛋白酶抑制剂(Mammary serine proteaseinhibitor,Maspin),突变型P53基因的表达,以探索它们在子宫内膜癌发生、进展过程中的作用,给临床诊断、治疗及预后判断提供新的理论依据.方法 采用链霉菌素抗生物素-过氧化物酶法(S-P法)研究子宫内膜不典型增生20例、子宫内膜癌42例、同期正常子宫内膜15例中Maspin和P53的表达情况.结果1. Maspin在三组的阳性表达率分别为40.5%、55.0%和86.7%;P53在三组的阳性表达率分别为69.0%、40.0%和13.3%;2. Maspin与P53的蛋白表达呈负相关.3. Maspin蛋白的表达与患者肿瘤分化程度、手术-病理分期、肌层浸润深度相关,与淋巴结转移无关.结论 Maspin与P53均参与了子宫内膜癌的发生及发展过程且二者相互作用,相互影响.
目的 通過檢測子宮內膜癌,子宮內膜不典型增生,正常子宮內膜中的絲氨痠蛋白酶抑製劑(Mammary serine proteaseinhibitor,Maspin),突變型P53基因的錶達,以探索它們在子宮內膜癌髮生、進展過程中的作用,給臨床診斷、治療及預後判斷提供新的理論依據.方法 採用鏈黴菌素抗生物素-過氧化物酶法(S-P法)研究子宮內膜不典型增生20例、子宮內膜癌42例、同期正常子宮內膜15例中Maspin和P53的錶達情況.結果1. Maspin在三組的暘性錶達率分彆為40.5%、55.0%和86.7%;P53在三組的暘性錶達率分彆為69.0%、40.0%和13.3%;2. Maspin與P53的蛋白錶達呈負相關.3. Maspin蛋白的錶達與患者腫瘤分化程度、手術-病理分期、肌層浸潤深度相關,與淋巴結轉移無關.結論 Maspin與P53均參與瞭子宮內膜癌的髮生及髮展過程且二者相互作用,相互影響.
목적 통과검측자궁내막암,자궁내막불전형증생,정상자궁내막중적사안산단백매억제제(Mammary serine proteaseinhibitor,Maspin),돌변형P53기인적표체,이탐색타문재자궁내막암발생、진전과정중적작용,급림상진단、치료급예후판단제공신적이론의거.방법 채용련매균소항생물소-과양화물매법(S-P법)연구자궁내막불전형증생20례、자궁내막암42례、동기정상자궁내막15례중Maspin화P53적표체정황.결과1. Maspin재삼조적양성표체솔분별위40.5%、55.0%화86.7%;P53재삼조적양성표체솔분별위69.0%、40.0%화13.3%;2. Maspin여P53적단백표체정부상관.3. Maspin단백적표체여환자종류분화정도、수술-병리분기、기층침윤심도상관,여림파결전이무관.결론 Maspin여P53균삼여료자궁내막암적발생급발전과정차이자상호작용,상호영향.
Objective By detecting endometrial carcinoma, atypical endometrial hyperplasia and normal endometrium in serine protease inhibitor of Maspin considerable serine proteaseinhibitor) and mutation type p53 gene expression and to explore them in endometrial cancer occurrence, development process, to clinical diagnosis, treatment and prognosis judgment provides new theoretical basis.Methods The Streptomyces) against biological biotin peroxidase method (S-P method) on endometrial atypical hyperplasia, the other 20 cases, 42 cases of endometrial carcinoma, compared with normal endometrium in 15 cases of Maspin and p53 expression.Results1 of maspin expression in three groups of rate was 40.5% and 55.0% and 86.7%; p53 in three groups, the positive expression rate was 69.0%, 40.0% and 13.3%; 2.Maspin and p53 protein expression was negatively correlated. 3 the expression of Maspin protein was correlated with tumor differentiation, operation and pathology stage and muscle invasion depth, and has no correlation with lymph node metastasis.Conclusion Maspin and P53 are involved in the development of endometrial cancer and the interaction of the two, the infl uence of the interaction.
