CAJ | 학술논문

目的探讨沙利度胺治疗肿瘤相关的厌食症的疗效及毒副作用.方法食欲评估采用数值评定量表评分35例符合条件的患者,给予沙利度胺起始50 mg,每晚1次的剂量,治疗两周后评价无反应者增加剂量至100 mg,每晚1次,两周后评价食欲、疲乏、睡眠、盗汗、疼痛、QOL.结果入组的35例患者中,33例完成了14天的治疗,64%的患者食欲得到改善,食欲、失眠、QOL的CAT评分显著提高.5例患者由于毒副作用退出试验.结论沙利度胺能显著改善肿瘤相关的厌食,减轻进展期患者失眠,并提高生活质量.
목적 탐토사리도알치료종류상관적염식증적료효급독부작용.방법 식욕평고채용수치평정량표평분35례부합조건적환자,급여사리도알기시50 mg,매만1차적제량,치료량주후평개무반응자증가제량지100 mg,매만1차,량주후평개식욕、피핍、수면、도한、동통、QOL.결과 입조적35례환자중,33례완성료14천적치료,64%적환자식욕득도개선,식욕、실면、QOL적CAT평분현저제고.5례환자유우독부작용퇴출시험.결론 사리도알능현저개선종류상관적염식,감경진전기환자실면,병제고생활질량.
Objective To assess appetite response to thaidomide in cancer-associated anorexia. Methods Loss of appetite was assessed by numerical rating scale(NRS). Pretreament screening included medical history, nrurologic examina-tion,and symptoms by NRS and categorical scale (CAT). Patients received 50mg of thalidomide by mouth at bedtime for two weeks. Individuals who did not respond were dose escalated to 100mg at night for two weeks.Assessment of appetite, tatigue, insomnia, night sweats, pain and quality of life (QOL)occurred at two-week intervas.Toxicity also was assessed. Results Thity-five patients entered the study;33completed 14 days of therapy and weie analyzed for efficacy and toxici-ty. Sixty-four percent who completed at least two weeks of thalidomide had improved appetite.The CAT scores for appe-tite,insomnia,and QOL improved significantly. Conclusion Thalidomide reduced multiple symptoms commonly associat-ed with cancer-related anorexia, such as appetite/insomnia/pain et al, and improved QOL.