CAJ | 학술논문

目的探讨食管癌手术对患者细胞免疫功能及应激激素水平影响.方法选取40例食管癌手术患者,检测食管癌手术前后细胞免疫功能及应激激素水平.细胞免疫功能判定因子CD3+、CD4+、NK细胞、CRP;应激激素水平判定因子GH、PRL、IL-8及Cor;所获数据采用方差分析和t检验.结果食管癌手术后患者的CD3+、CD4+及NK细胞表达水平有所下降,而CRP表达水平有所上升,手术前后细胞免疫功能判定因子具有显著性差异(P<0.05);食管癌手术后患者的GH、PRL及Cor表达水平有所上升,而IL-8表达水平有所下降,手术前后应激激素水平具有显著性差异(P<0.05).结论食管癌手术对患者的细胞免疫功能具有抑制作用及应激创伤性,可作为监控食管癌手术的观察指标.
목적 탐토식관암수술대환자세포면역공능급응격격소수평영향.방법 선취40례식관암수술환자,검측식관암수술전후세포면역공능급응격격소수평.세포면역공능판정인자CD3+、CD4+、NK세포、CRP;응격격소수평판정인자GH、PRL、IL-8급Cor;소획수거채용방차분석화t검험.결과식관암수술후환자적CD3+、CD4+급NK세포표체수평유소하강,이CRP표체수평유소상승,수술전후세포면역공능판정인자구유현저성차이(P<0.05);식관암수술후환자적GH、PRL급Cor표체수평유소상승,이IL-8표체수평유소하강,수술전후응격격소수평구유현저성차이(P<0.05).결론 식관암수술대환자적세포면역공능구유억제작용급응격창상성,가작위감공식관암수술적관찰지표.
Objective To observe the influence of esophageal cancer operation on cellular immune function and stress hormone level of patients. Methods 40 patients receiving esophageal cancer operation were selected as research ob-jects. The cellular immune function and stress hormone level of patients before and after operation was compared. Cellular immune function judged CD3+, CD4+, NK cell and CRP. Stress hormone level judged GH, PRL, IL-8 a nd Cor. The data ob-tained using andysis of variance and t test. Results The expression level of CD3+, CD4+and NK cell of patients after esophageal cancer operation reduced, but tat of CRP increased. There was statistical difference for cellular immune function judging factors before and after operation (P<0.05). The expression level of GH, PRL and Cor of patients after esophageal cancer operation reduced, but that of IL-8 increased. There was statistical difference for stress hormone level before and af-ter operation (P<0.05). Conclusion Esophageal cancer operation has inhibition function and traumatic stress for cellular immune function of patients, which can be used as observation indicator for monitoring esophageal cancer operation.