CAJ | 학술논문

目的：比较度洛西汀与帕罗西汀治疗抑郁症合并躯体症状的临床疗效。方法将42例抑郁症合并躯体症状患者随机分为两组，分别予以度洛西汀、帕罗西汀治疗。于治疗前后采用汉密顿抑郁量表、副反应量表评定疗效及不良反应。结果度洛西汀组显效率高于帕罗西汀组，但差异无显著性（P ＞0．05）。治疗后两组汉密顿抑郁量表总分均较治疗前显著降低（P＜0．01），治疗2周末度洛西汀组较帕罗西汀组下降更显著（P＜0．01）；治疗4周、6周末两组躯体化焦虑因子分较治疗2周末显著降低（P＜0．01），且度洛西汀组较帕罗西汀组下降更显著（ P＜0．05或0．01）。两组不良反应无明显差异性。结论度洛西汀与帕罗西汀治疗抑郁症合并躯体症状疗效显著且相当，度洛西汀改善躯体症状的效果更佳。
목적：비교도락서정여파라서정치료억욱증합병구체증상적림상료효。방법장42례억욱증합병구체증상환자수궤분위량조，분별여이도락서정、파라서정치료。우치료전후채용한밀돈억욱량표、부반응량표평정료효급불량반응。결과도락서정조현효솔고우파라서정조，단차이무현저성（P ＞0．05）。치료후량조한밀돈억욱량표총분균교치료전현저강저（P＜0．01），치료2주말도락서정조교파라서정조하강경현저（P＜0．01）；치료4주、6주말량조구체화초필인자분교치료2주말현저강저（P＜0．01），차도락서정조교파라서정조하강경현저（ P＜0．05혹0．01）。량조불량반응무명현차이성。결론도락서정여파라서정치료억욱증합병구체증상료효현저차상당，도락서정개선구체증상적효과경가。
Objective To compare the efficacy between duloxetine and paroxetine in depression complicat‐ed with somatic symptoms .Methods Forty‐two depression patients complicated with somatic symptoms were randomly assigned to two groups treated with duloxetine or paroxetine .Efficacies were assessed with the Hamilton Depression Scale (HAMD) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) before and after treatment .Results Obvious effective rate was higher in duloxetine than in paroxetine group ,but difference weren’t significant (P>0 .05) .The total scores of the HAMD of both groups lowered more significantly compared with pretreatment (P<0 .01) ,so did that in duloxetine than in paroxetine group at the end of the 2nd week (P<0 .05 or 0 .01);somatization anxiety scores of both groups lower ed significantly at the end of the 4th and 6th week than at the end of the 2nd (P<0 .01) ,so did those in duloxetine than in paroxetine group at the end of 4th and 6th week .There were no significant group differences in adverse reactions .Conclusion Duloxetine and paroxetine have an equivalent evident effect in depression complicated with somatic symptoms ,the former has an advantage in improving somatic symp‐toms over the latter .