CAJ | 학술논문

目的：探讨中医治疗精神分裂症药源性闭经的临床疗效。方法将60例精神分裂症药源性闭经患者随机分为两组，每组30例，均维持原用抗精神病药物治疗，研究组联合中药血府逐瘀汤加减治疗，观察12周。治疗前后采用临床总体疗效评定量表评定临床疗效，副反应量表评定不良反应，并记录月经恢复状况。结果治疗后两组临床总体疗效评定量表评分呈逐渐下降趋势，同期两组间评分比较差异无显著性（P＞0．05）；两组均未出现明显不良反应，副反应量表评分比较差异无显著性（ P＞0．05）。治疗12周末研究组月经恢复总有效率为93．3％，对照组闭经状况均无改善（未来月经），研究组总有效率显著高于对照组（P＜0．01）。结论中医药治疗精神分裂症药源性闭经疗效显著，安全性高。
목적：탐토중의치료정신분렬증약원성폐경적림상료효。방법장60례정신분렬증약원성폐경환자수궤분위량조，매조30례，균유지원용항정신병약물치료，연구조연합중약혈부축어탕가감치료，관찰12주。치료전후채용림상총체료효평정량표평정림상료효，부반응량표평정불량반응，병기록월경회복상황。결과치료후량조림상총체료효평정량표평분정축점하강추세，동기량조간평분비교차이무현저성（P＞0．05）；량조균미출현명현불량반응，부반응량표평분비교차이무현저성（ P＞0．05）。치료12주말연구조월경회복총유효솔위93．3％，대조조폐경상황균무개선（미래월경），연구조총유효솔현저고우대조조（P＜0．01）。결론중의약치료정신분렬증약원성폐경료효현저，안전성고。
Objective To explore the efficacy of TCM treatment for schizophrenia with drug‐induced amenorrhea .Methods Sixty schizophrenics with drug‐induced amenorrhea were ran‐domly assigned to two groups of 30 ones each ,both groups maintained original antipsychotic treatment , research group was plus traditional Chinese drug of xuefu zhuyu tang for 12 weeks .Efficacies were assessed with the Clinical Global Impression (CGI) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) before and after treatment ,menstruation recovery states recorded .Results After treatment the CGI scores of both groups lowered gradually ,there were no significant group differences in the corre‐sponding period (P>0 .05) .Both groups had no obvious adverse reactions ,the TESS score did no signifi‐cant group difference (P>0 .05) .At the end of the 12th week total effective rate of menstruation recovery was 93 .3% in research group ,amenorrhea status didn’t improve in control group ,the total effective rate was significantly higher in research than in control group (P<0 .01) .Conclusion TCM treatment has an evident effect and higher safety for schizophrenia with drug‐induced amenorrhea .