CAJ | 학술논문

目的：探讨齐拉西酮对男性精神分裂症患者临床疗效及生活质量的影响。方法将66例男性精神分裂症患者随机分为两组，每组33例，研究组口服齐拉西酮治疗，对照组口服利培酮治疗，观察10周。于治疗前后采用简明精神病评定量表评定临床疗效，副反应量表评定不良反应，生活质量综合评定问卷评定生活质量。结果治疗后两组简明精神病评定量表评分均较治疗前显著下降（P＜0．01），两组间评分比较差异均无显著性（P＞0．05）。两组不良反应较轻微，研究组总体不良反应发生率以及锥体外系反应、体质量增加发生率显著低于对照组（P＜0．05）。治疗10周末研究组生活质量综合评定问卷总分及身体健康、心理健康维度分显著高于对照组（ P＜0．05或0．01）。结论齐拉西酮治疗男性精神分裂症疗效显著且与利培酮相当，不良反应发生率低、治疗依从性好，有利于提高患者的生活质量。
목적：탐토제랍서동대남성정신분렬증환자림상료효급생활질량적영향。방법장66례남성정신분렬증환자수궤분위량조，매조33례，연구조구복제랍서동치료，대조조구복리배동치료，관찰10주。우치료전후채용간명정신병평정량표평정림상료효，부반응량표평정불량반응，생활질량종합평정문권평정생활질량。결과치료후량조간명정신병평정량표평분균교치료전현저하강（P＜0．01），량조간평분비교차이균무현저성（P＞0．05）。량조불량반응교경미，연구조총체불량반응발생솔이급추체외계반응、체질량증가발생솔현저저우대조조（P＜0．05）。치료10주말연구조생활질량종합평정문권총분급신체건강、심리건강유도분현저고우대조조（ P＜0．05혹0．01）。결론제랍서동치료남성정신분렬증료효현저차여리배동상당，불량반응발생솔저、치료의종성호，유리우제고환자적생활질량。
Objective To explore the influence of ziprasidone on efficacy and quality of life of male schizo‐phrenia .Methods Sixty‐six male schizophrenics were randomly assigned to two groups of 33 ones each , research group took orally ziprasidone and control group did risperidone for 10 weeks .Efficacies were as‐sessed with the Brief Psychiatric Rating Scale (BPRS) ,adverse reactions with the Treatment Emergent Symptom Scale (TESS) ,and qualities with the Generic Quality of Life Inventory‐74 (GQOLI‐74) before and after treatment .Results After treatment the BPRS scores of both groups lowered more significantly (P< 0 .01) and those had no significant group difference (P>0 .05) .Adverse reactions of both groups were mild ,the incidence of total ,extrapyramidal side effects and weight gain were significantly lower in research than in control group (P<0 .05) .At the end of the 10th week the total ,physical health and men‐tal health score were significantly higher in research than in control group (P<0 .05 or 0 .01) .Conclusion Ziprasidone has an evident effect equivalent to risperidone ,lower incidence of adverse reaction and better compliance in male schizophrenia and is beneficial to the improvement of quality of life .