CAJ | 학술논문

目的：探讨帕利哌酮缓释片与利培酮治疗男性急性精神分裂症患者的临床疗效和安全性，以及对社会功能影响。方法将80例男性急性精神分裂患者随机分为两组，每组40例，研究组口服帕利哌酮缓释片治疗，对照组口服利培酮治疗，观察12周。治疗前后采用阳性与阴性症状量表评定临床疗效，个人和社会功能量表评定社会功能，副反应量表评定不良反应。结果治疗12周末两组阳性与阴性症状量表总分及各因子分均较治疗前显著下降（ P＜0．01），研究组较对照组下降更显著（P＜0．01）；两组个人和社会功能量表总分较治疗前显著升高（P＜0．01），研究组较对照组升高更显著（ P＜0．01）；研究组总有效率为85．0％，对照组为75．0％，两组比较差异无显著性（χ2＝2．54，P＞0．05）；研究组不良反应发生率为20．0％，对照组为42．5％，研究组不良反应发生率显著低于对照组（χ2＝4．71，P＜0．05）。结论帕利哌酮缓释片与利培酮均能有效改善男性急性精神分裂症患者的各种精神症状和社会功能，但帕利哌酮缓释片改善社会功能方面优于利培酮，安全性更高。
목적：탐토파리고동완석편여리배동치료남성급성정신분렬증환자적림상료효화안전성，이급대사회공능영향。방법장80례남성급성정신분렬환자수궤분위량조，매조40례，연구조구복파리고동완석편치료，대조조구복리배동치료，관찰12주。치료전후채용양성여음성증상량표평정림상료효，개인화사회공능량표평정사회공능，부반응량표평정불량반응。결과치료12주말량조양성여음성증상량표총분급각인자분균교치료전현저하강（ P＜0．01），연구조교대조조하강경현저（P＜0．01）；량조개인화사회공능량표총분교치료전현저승고（P＜0．01），연구조교대조조승고경현저（ P＜0．01）；연구조총유효솔위85．0％，대조조위75．0％，량조비교차이무현저성（χ2＝2．54，P＞0．05）；연구조불량반응발생솔위20．0％，대조조위42．5％，연구조불량반응발생솔현저저우대조조（χ2＝4．71，P＜0．05）。결론파리고동완석편여리배동균능유효개선남성급성정신분렬증환자적각충정신증상화사회공능，단파리고동완석편개선사회공능방면우우리배동，안전성경고。
Objective Objective To explore the efficacy and safety of paliperidone extended‐release (pali‐peridone ER) tablets and risperidone in male acute schizophrenic and their influence on social function . Methods Eighty male acute schizophrenics were randomly divided into two groups of 40 ones each ,re‐search group took orally paliperidone ER and control group did risperidone for 12 weeks .Before and after treatment efficacies were assessed with the Positive and Negative Syndrome Scale (PANSS ) ,social per‐formances with the Personal and Social Performance Scale (PSP) ,and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results At the end of the 12th week the total and each factor scores of the PANSS of both groups lowered more significantly compared with pretreatment (P< 0 .01) ,so did those in research than in control group (P<0 .01);the total scores of the PSP of both groups heightened more significantly (P<0 .01) ,so did that in research than in control group (P<0 .01);total effective rate was respectively 85 .0% in research and 75 .0% in control group ,which showed no significant difference (χ2 =2 .54 ,P>0 .05);the incidence was respectively 20 .0% in research and 42 .5% in control group ,the former significantly lower than the latter (χ2 =4 .71 ,P<0 .05) .Conclusion Both paliperidone ER and risperidone could effectively improve various kinds of mental symptoms and social performances ,but the former has an advantage in improving social performances and higher safety over the latter .