CAJ | 학술논문

为验证矮膜苞芹的降血糖作用，建立四氧嘧啶诱导的昆明小鼠糖尿病模型，将50只小鼠分为正常对照组(等容蒸馏水)、模型组(等容蒸馏水)、二甲双胍组(200 mg/kg)与矮膜苞芹低剂量组(10 g/kg)、高剂量组(20 g/kg)，每组10只.灌胃给药，每天1次，连续21 d.每天记录小鼠进食量及饮水量，每周称体重1次，分别于第7天、第14天、第21天测定小鼠血糖值.结果表明，与正常对照组相比，模型组小鼠血糖值显著升高(P ＜0．01)；与模型组相比，矮膜苞芹具有明显降低糖尿病小鼠血糖的作用(P ＜0．05或 P ＜0．01)，并存在一定的剂量依赖关系，且矮膜苞芹具有促进糖尿病小鼠体重恢复及缓解糖尿病小鼠多饮、多食症状的作用.
위험증왜막포근적강혈당작용，건립사양밀정유도적곤명소서당뇨병모형，장50지소서분위정상대조조(등용증류수)、모형조(등용증류수)、이갑쌍고조(200 mg/kg)여왜막포근저제량조(10 g/kg)、고제량조(20 g/kg)，매조10지.관위급약，매천1차，련속21 d.매천기록소서진식량급음수량，매주칭체중1차，분별우제7천、제14천、제21천측정소서혈당치.결과표명，여정상대조조상비，모형조소서혈당치현저승고(P ＜0．01)；여모형조상비，왜막포근구유명현강저당뇨병소서혈당적작용(P ＜0．05혹 P ＜0．01)，병존재일정적제량의뢰관계，차왜막포근구유촉진당뇨병소서체중회복급완해당뇨병소서다음、다식증상적작용.
The diabetic mice model was induced by alloxan,then 50 mice were divided into normal control group (constant volume of distilled water),model group (constant volume of distilled water),metformin group (200 mg/kg),H ymenoleana nana low-dose and high-dose groups (10 g/kg,20 g/kg),each group for 10 mice.Mice were given relevant medicine intragastrically once a day for consecutive 21 days.Food-intake and water-intake were recorded everyday,and body weight was recorded weekly.Blood glucose was meas-ured on the 7th,14th,and 21st intragastrically.Compared with normal control group,the blood glucose of mice in model group was increased significantly (P <0.01).Compared with model group,H ymenoleana na-na potently decreased the blood glucose (P <0.05 or P < 0.01)in a dose-dependent manner.Furthermore, H ymenoleana nana could increase the body weight of diabetic mice and alleviate polydipsia and polyphagia of diabetic mice.