世界最新医学信息文摘（连续型电子期刊）
世界最新醫學信息文摘（連續型電子期刊）
세계최신의학신식문적（련속형전자기간）
World Latest Medicine Information
2015年
34期
65-66
,共2页
丙烯酰胺%超氧化物歧化酶%神经行为%抗氧化能力
丙烯酰胺%超氧化物歧化酶%神經行為%抗氧化能力
병희선알%초양화물기화매%신경행위%항양화능력
Acrylamide%superoxide dismutase%Neurobehavior%Antioxidant capacity
目的 观察丙烯酰胺(Acrylamide,ACR)对雄性大鼠一般神经行为和血清中超氧化物歧化酶(superoxide dismutase, SOD)活性的影响.方法 选用Wistar雄性大鼠18只随机分成ACR组和对照组,ACR组以1ml/100g的剂量每天腹腔注射ACR,对照组给予等量生理盐水.连续注射11天,每天称重,每隔三天监测大鼠的甩尾反射和步态评分.于第12天处死大鼠,进行血清T-SOD活性检测.结果 与对照组相比,ACR组大鼠甩尾时间显著降低(P<0.05),步态评分显著升高(P<0.001),血清中T-SOD活性降低(P<0.001),差异有统计学意义.结论 ACR能引起大鼠神经行为功能的改变,同时降低了大鼠的抗氧化能力.
目的 觀察丙烯酰胺(Acrylamide,ACR)對雄性大鼠一般神經行為和血清中超氧化物歧化酶(superoxide dismutase, SOD)活性的影響.方法 選用Wistar雄性大鼠18隻隨機分成ACR組和對照組,ACR組以1ml/100g的劑量每天腹腔註射ACR,對照組給予等量生理鹽水.連續註射11天,每天稱重,每隔三天鑑測大鼠的甩尾反射和步態評分.于第12天處死大鼠,進行血清T-SOD活性檢測.結果 與對照組相比,ACR組大鼠甩尾時間顯著降低(P<0.05),步態評分顯著升高(P<0.001),血清中T-SOD活性降低(P<0.001),差異有統計學意義.結論 ACR能引起大鼠神經行為功能的改變,同時降低瞭大鼠的抗氧化能力.
목적 관찰병희선알(Acrylamide,ACR)대웅성대서일반신경행위화혈청중초양화물기화매(superoxide dismutase, SOD)활성적영향.방법 선용Wistar웅성대서18지수궤분성ACR조화대조조,ACR조이1ml/100g적제량매천복강주사ACR,대조조급여등량생리염수.련속주사11천,매천칭중,매격삼천감측대서적솔미반사화보태평분.우제12천처사대서,진행혈청T-SOD활성검측.결과 여대조조상비,ACR조대서솔미시간현저강저(P<0.05),보태평분현저승고(P<0.001),혈청중T-SOD활성강저(P<0.001),차이유통계학의의.결론 ACR능인기대서신경행위공능적개변,동시강저료대서적항양화능력.
Objective To explore the effect of acrylamide on general neurobehavior and T-SOD activity in serum of male rats. MethodsEighteen male rats were randomly divided into 2 Groups: ACR exposed group(1ml/100g) and control group. Injection of 11 days in a row, weighing every day, every three days monitoring rats tail reflection time and gait scores.Rats were put to death in the 12 th day, then detect T-SOD activity in serum.ResultsIn comparison with control,there were significant differences in neurobehavioral indexes, rats tail reflection time(P<0.05), gait score(P<0.001), T-SODactivity(P<0.001). Conclusion:Acrylamide may affect crylamide of rats and decrease antioxidant capacity.
