CAJ | 학술논문

Z系药物（由唑吡坦、佐匹克隆和扎来普隆组成）作为新型安眠镇静类药物比传统苯二氮卓菒类药物具有更大优势。Z系药物虽然不会明显增加睡眠时间，但是能够减少入睡时间并改善睡眠质量，具有显著的催眠效果。 Z系药物的作用机理类似于苯二氮卓菒类药物，主要通过增加γ－氨基丁酸的传输来发挥作用。 Z系药物的过量摄入很少会引起死亡，更多是导致中毒。血液、尿液、唾液和组织样本中Z系药物可通过色谱－质谱技术检测，其中唑吡坦和扎来普隆会表现出明显的死后再分布。尽管Z系药物在药代动力学方面有所改变，但由其引起的神经后遗症、中毒和死亡等后果，则和其他安眠镇静类药物相似。本文主要从药理学和毒理学角度，对Z系药物的副作用、毒性以及法医毒理数据进行重点介绍和分析。
Z계약물（유서필탄、좌필극륭화찰래보륭조성）작위신형안면진정류약물비전통분이담탁고류약물구유경대우세。Z계약물수연불회명현증가수면시간，단시능구감소입수시간병개선수면질량，구유현저적최면효과。 Z계약물적작용궤리유사우분이담탁고류약물，주요통과증가γ－안기정산적전수래발휘작용。 Z계약물적과량섭입흔소회인기사망，경다시도치중독。혈액、뇨액、타액화조직양본중Z계약물가통과색보－질보기술검측，기중서필탄화찰래보륭회표현출명현적사후재분포。진관Z계약물재약대동역학방면유소개변，단유기인기적신경후유증、중독화사망등후과，칙화기타안면진정류약물상사。본문주요종약이학화독이학각도，대Z계약물적부작용、독성이급법의독리수거진행중점개소화분석。
The Z-drugs (zolpidem , zopiclone, and zaleplon), as the innovative hypnotics, have an im-provem ent over the traditional benzodiazepines in the m anagem ent of insom nia. Z-drugs have significant hypnotic effects by reducing sleep latency and im proving sleep quality, though duration of sleep m ay not be significantly increased. A s benzodiazepines, Z-drugs exert their effects through increasing the trans-m ission ofγ-am inobutyric acid. Z-drugs overdose are less likely to be fatal, m ore likely w ould result in poisoning. Z-drugs can be detected in blood, urine, saliva, and other postm ortem specim ens through liq-uid chrom atography-m ass spectrom etry techniques. Z olpidem and zaleplon exhibit significant postm ortem redistribution. Z-drugs have im proved pharm acokinetic profiles, but incidence of neuropsychiatric seque-lae, poisoning, and death m ay prove to be sim ilar to the other hypnotics. This review focuses on the pharm acology and toxicology of Z-drugs w ith respect to their adverse effect profile and toxicity and toxicology data in the field of forensic m edicine.