Efficient removal of uranium from mice by a novel compound of fullerence multi-macrocyclic polyamine derivatives
  • 万方数据
    核技术（英文版） 핵기술（영문판）
    NUCLEAR SCIENCE AND TECHNIQUES
    2015年 4期 040302-1-040302-8 ,共1页

    刘晓青%杨远友%廖家莉%欧巍%孔芳%兰静波%罗顺忠%刘国平%何佳恒%杨吉军%唐军%刘宁

    류효청%양원우%료가리%구외%공방%란정파%라순충%류국평%하가항%양길군%당군%류저



    Uranium%Internal contamination%Removal%Fullerence multi-macrocyclic polyamine derivatives (C60-MMP)


    Uranium removal efficacy of fullerence multi-macrocyclic polyamine derivatives (C60-MMP), a novel chelat-ing agent, was evaluated in mice. C60-MMP was administrated intravenously into mice at 30 min after the uranium contamination. The molar ratio of chelating ligand/uranium was about 1:1. The results indicate that C60-MMP can effectively prevent accumulation of uranium in liver at 8 h after C60-MMP injection. At 48 h af-ter the last injection, uranium deposition in liver of C60-MMP treated mice is approximately 65%less than that of the control group. C60-MMP reacted positively in promoting the removal of uranium from kidney, and the urinary uranium excretion increased significantly, compared with the control and DTPA-treated mice. However, repeated administration of C60-MMP, and combined injection of DTPA and C60-MMP, did not show desirable effects on uranium removal from mice. It implies that more investigations are needed for the treatment protocols and clinical applications of C60-MMP.
    원문보기 원문다운로드 사이트로이동
저자의 최근 논문