中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2015年
3期
231-235
,共5页
刘敏%王莹%金木兰%郭晓娟%王双坤%李杰%刘军%张红霞
劉敏%王瑩%金木蘭%郭曉娟%王雙坤%李傑%劉軍%張紅霞
류민%왕형%금목란%곽효연%왕쌍곤%리걸%류군%장홍하
乳腺浸润性导管癌%血氧水平依赖功能磁共振成像%葡萄糖转运蛋白1
乳腺浸潤性導管癌%血氧水平依賴功能磁共振成像%葡萄糖轉運蛋白1
유선침윤성도관암%혈양수평의뢰공능자공진성상%포도당전운단백1
Breast invasive ductal carcinoma%Blood oxygenation level-dependent functional magnetic resonance imaging%Glucose transporter-1
目的 探讨血氧水平依赖功能磁共振成像(BOLD-fMRI)的R2*值与乳腺浸润性导管癌组织葡萄糖转运蛋白1 (GLUT-1)表达的相关性.方法 回顾性分析2011年12月至2013年6月本院接受乳腺癌手术治疗且术后病理证实为乳腺浸润性导管癌患者77例的临床资料,所有患者均于术前行乳腺BOLD-fMRI检查并测定肿瘤组织的R2*值.免疫组化染色检测肿瘤组织GLUT-1的表达.Spearman相关分析肿瘤组织BOLD-fMRI R2*值与GLUT-1表达的关系.结果 病理学检查显示77例患者均为乳腺浸润性导管癌,肿瘤分级为Ⅰ级3例、Ⅱ级48例、Ⅲ级26例,其中伴腋窝淋巴结转移40例.免疫组化显示肿瘤组织GLUT-1表达阴性6例、弱阳性11例、中度阳性25例、强阳性35例,GLUT-1表达阳性率为92.2%(71/77).腋窝淋巴结转移组GLUT-1表达显著高于无腋窝淋巴结转移组(x2=5.718,P=0.016).BOLD-fMRI检查显示乳腺浸润性导管癌呈混杂信号,R2*值为26.4~90.5 Hz,平均(54.9±16.9)Hz.Spearman相关分析表明,乳腺浸润性导管癌肿瘤组织R2*值与GLUT-1的表达呈正相关(r=0.587,P=0.000).结论 BOLD-fMRI可用于无创性评价乳腺浸润性导管癌组织慢性乏氧及葡萄糖代谢水平.
目的 探討血氧水平依賴功能磁共振成像(BOLD-fMRI)的R2*值與乳腺浸潤性導管癌組織葡萄糖轉運蛋白1 (GLUT-1)錶達的相關性.方法 迴顧性分析2011年12月至2013年6月本院接受乳腺癌手術治療且術後病理證實為乳腺浸潤性導管癌患者77例的臨床資料,所有患者均于術前行乳腺BOLD-fMRI檢查併測定腫瘤組織的R2*值.免疫組化染色檢測腫瘤組織GLUT-1的錶達.Spearman相關分析腫瘤組織BOLD-fMRI R2*值與GLUT-1錶達的關繫.結果 病理學檢查顯示77例患者均為乳腺浸潤性導管癌,腫瘤分級為Ⅰ級3例、Ⅱ級48例、Ⅲ級26例,其中伴腋窩淋巴結轉移40例.免疫組化顯示腫瘤組織GLUT-1錶達陰性6例、弱暘性11例、中度暘性25例、彊暘性35例,GLUT-1錶達暘性率為92.2%(71/77).腋窩淋巴結轉移組GLUT-1錶達顯著高于無腋窩淋巴結轉移組(x2=5.718,P=0.016).BOLD-fMRI檢查顯示乳腺浸潤性導管癌呈混雜信號,R2*值為26.4~90.5 Hz,平均(54.9±16.9)Hz.Spearman相關分析錶明,乳腺浸潤性導管癌腫瘤組織R2*值與GLUT-1的錶達呈正相關(r=0.587,P=0.000).結論 BOLD-fMRI可用于無創性評價乳腺浸潤性導管癌組織慢性乏氧及葡萄糖代謝水平.
목적 탐토혈양수평의뢰공능자공진성상(BOLD-fMRI)적R2*치여유선침윤성도관암조직포도당전운단백1 (GLUT-1)표체적상관성.방법 회고성분석2011년12월지2013년6월본원접수유선암수술치료차술후병리증실위유선침윤성도관암환자77례적림상자료,소유환자균우술전행유선BOLD-fMRI검사병측정종류조직적R2*치.면역조화염색검측종류조직GLUT-1적표체.Spearman상관분석종류조직BOLD-fMRI R2*치여GLUT-1표체적관계.결과 병이학검사현시77례환자균위유선침윤성도관암,종류분급위Ⅰ급3례、Ⅱ급48례、Ⅲ급26례,기중반액와림파결전이40례.면역조화현시종류조직GLUT-1표체음성6례、약양성11례、중도양성25례、강양성35례,GLUT-1표체양성솔위92.2%(71/77).액와림파결전이조GLUT-1표체현저고우무액와림파결전이조(x2=5.718,P=0.016).BOLD-fMRI검사현시유선침윤성도관암정혼잡신호,R2*치위26.4~90.5 Hz,평균(54.9±16.9)Hz.Spearman상관분석표명,유선침윤성도관암종류조직R2*치여GLUT-1적표체정정상관(r=0.587,P=0.000).결론 BOLD-fMRI가용우무창성평개유선침윤성도관암조직만성핍양급포도당대사수평.
Objective To investigate the correlation between R2* value of blood oxygenation leveldependent functional magnetic resonance imaging (BOLD-fMRI) and glucose transporter-1 (GLUT-1) of breast invasive ductal carcinoma (IDC).Methods Clinical data of 77 women who underwent breast cancer surgery in our hospital and were pathologically confirmed to be with IDC between December 2011 and June 2013 were retrospectively analyzed.Before surgery,these patients received BOLD-fMRI with measurement of tumor R2* value.The expression of GLUT-1 in cancer tissues was evaluated by immuuohistochemical analysis.Spearman correlation analysis was performed on the relationship between BOLD-fMRI R2* value and GLUT-1 expression in the cancer tissues.Results Pathological study identified IDC in all of the 77 patients,including 3 with grade Ⅰ,48 with grade Ⅱ and 26 with grade Ⅲ lesions.Axillary metastasis was detected in 40 patients.GLUT-1 expression of cancer tissues was negative in 6 cases,weak-positive in 11,moderatepositive in 25,and strong-positive in 35 cases,corresponding to a positive rate of 92.2% (71/77).Patients with axillary metastasis had significantly stronger GLUT-1 expression than those without axillary metastasis (x2=5.718,P=0.016).IDCs showed relatively heterogeneous intensity on BOLD-fMR images.The mean R2* value of 77 lesions was (54.9± 16.9) Hz (range:26.4 to 90.5 Hz).R2* value was positively correlated with the expression of GLUT-1 (r=0.587,P=0.000) by Spearman correlation analysis.Conclusion BOLD-fMRI can be used for non-invasive evaluation of the chronic hypoxia and glucose metabolism in IDC tissue.