中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2015年
3期
236-241
,共6页
努尔布维·吐尔孙%姚晓光%周玲%洪静%李南方
努爾佈維·吐爾孫%姚曉光%週玲%洪靜%李南方
노이포유·토이손%요효광%주령%홍정%리남방
锌指蛋白36%基因多态性%甘油三酯%维吾尔族
鋅指蛋白36%基因多態性%甘油三酯%維吾爾族
자지단백36%기인다태성%감유삼지%유오이족
Zinc finger protein 36%Gene polymorphism%Triglyceride%Uygur
目的 探讨锌指蛋白36(ZFP36)基因多态性与新疆维吾尔族人群血清甘油三酯的关联性.方法 采用流行病学调查为基础的病例对照研究,选取932例维吾尔族人群为研究对象.选取肥胖维吾尔族人48例进行测序筛查ZFP36基因功能区的变异位点,选取代表性变异位点进行研究人群基因型鉴定,按血清甘油三酯(TG)水平分为TG正常组、TG边缘升高组和TG升高组,探讨ZFP36基因多态性与新疆维吾尔族人群血清TG的关系.结果 在ZFP36基因的功能区共发现1个新的和3个已知的变异位点.ZFP36基因的2个代表性变异位点rs251864和rs3746083均符合HardyWeinberg平衡.维吾尔族女性TG正常组、TG边缘升高组和TG升高组中rs251864变异位点AA、AG、GG基因型分布比较,差异有统计学意义(P=0.038).Logistic回归分析提示维吾尔族女性人群中rs251864变异GG基因型是肥胖的保护性因素(OR=0.621,95％CI:0.421～0.914,P=0.016).结论锌指蛋白36基因变异位点rs251864可能与新疆维吾尔族女性血清TG相关.
目的 探討鋅指蛋白36(ZFP36)基因多態性與新疆維吾爾族人群血清甘油三酯的關聯性.方法 採用流行病學調查為基礎的病例對照研究,選取932例維吾爾族人群為研究對象.選取肥胖維吾爾族人48例進行測序篩查ZFP36基因功能區的變異位點,選取代錶性變異位點進行研究人群基因型鑒定,按血清甘油三酯(TG)水平分為TG正常組、TG邊緣升高組和TG升高組,探討ZFP36基因多態性與新疆維吾爾族人群血清TG的關繫.結果 在ZFP36基因的功能區共髮現1箇新的和3箇已知的變異位點.ZFP36基因的2箇代錶性變異位點rs251864和rs3746083均符閤HardyWeinberg平衡.維吾爾族女性TG正常組、TG邊緣升高組和TG升高組中rs251864變異位點AA、AG、GG基因型分佈比較,差異有統計學意義(P=0.038).Logistic迴歸分析提示維吾爾族女性人群中rs251864變異GG基因型是肥胖的保護性因素(OR=0.621,95％CI:0.421～0.914,P=0.016).結論鋅指蛋白36基因變異位點rs251864可能與新疆維吾爾族女性血清TG相關.
목적 탐토자지단백36(ZFP36)기인다태성여신강유오이족인군혈청감유삼지적관련성.방법 채용류행병학조사위기출적병례대조연구,선취932례유오이족인군위연구대상.선취비반유오이족인48례진행측서사사ZFP36기인공능구적변이위점,선취대표성변이위점진행연구인군기인형감정,안혈청감유삼지(TG)수평분위TG정상조、TG변연승고조화TG승고조,탐토ZFP36기인다태성여신강유오이족인군혈청TG적관계.결과 재ZFP36기인적공능구공발현1개신적화3개이지적변이위점.ZFP36기인적2개대표성변이위점rs251864화rs3746083균부합HardyWeinberg평형.유오이족녀성TG정상조、TG변연승고조화TG승고조중rs251864변이위점AA、AG、GG기인형분포비교,차이유통계학의의(P=0.038).Logistic회귀분석제시유오이족녀성인군중rs251864변이GG기인형시비반적보호성인소(OR=0.621,95％CI:0.421～0.914,P=0.016).결론자지단백36기인변이위점rs251864가능여신강유오이족녀성혈청TG상관.
Objective To investigate the correlation between the zinc finger protein 36 (ZFP36) gene polymorphism and serum triglyceride (TG) in Uygur population in Xinjiang province.Methods A case-control study was conducted based on epidemiological investigation.A total of 932 Uygur were included as the subjects in this study.The variation sites in ZFP36 gene functional region were sequenced and screened in 48 obese Uygur.The representative variation sites were selected to identify the genotype of Uygur population,and were divided into the normal TG level group,borderline high TG level group,and high TG level group according to the serum TG levels.The correlation between the ZFP36 gene polymorphism and serum TG in Uygur population in Xinjiang province was investigated.Results One novel and three known variation sites in the ZFP36 gene functional region were identified.Two representative variation sites rs251864 and rs3746083 of ZFP36 gene were consistent with Hardy-Weinberg equilibrium.There were statistically significant differences in the AA,AG and GG genotype distribution of rs251864 variation site among the normal TG level group,borderline high TG level group,and high TG level group in Uygur females (P=0.038).Logistic regression analysis showed that GG genotype of rs251864 variation site might be a protective factor of obesity in Uygur females (OR=0.621,95％ CI:0.421-0.914,P=0.016).Conclusion The ZFP36 gene variation site rs251864 may be correlated with serum TG in Uygur females.
