CAJ | 학술논문

核因子E2相关因子2（nuclear factor E2 related factor 2，Nrf2）是机体抗氧化应激的中枢调节者。在正常情况下，其在胞质中被降解，不发挥生理作用。当其在体内被有毒有害物质激活后转位进入细胞核能与抗氧化反应元件（antioxidant response element，ARE）结合形成Nrf2-ARE信号通路，从而使下游一系列具有机体保护性的Ⅱ相解毒酶和抗氧化酶基因及蛋白得以表达，主要包括过氧化氢酶（CAT）、超氧化物歧化酶（SOD）、醌氧化还原酶1（NQO1）以及血红素加氧酶1（HO-1）。这些被激活的保护性酶类能够参与体内的广泛调节作用，对人体进行多方面的保护，研究发现该通路与机体炎症、肿瘤、衰老、凋亡、神经损伤、生育、妇产科疾病等多方面均有密切联系。综述Nrf2-ARE信号通路功能的研究进展，旨在全面客观地认识其生理功能。
핵인자E2상관인자2（nuclear factor E2 related factor 2，Nrf2）시궤체항양화응격적중추조절자。재정상정황하，기재포질중피강해，불발휘생리작용。당기재체내피유독유해물질격활후전위진입세포핵능여항양화반응원건（antioxidant response element，ARE）결합형성Nrf2-ARE신호통로，종이사하유일계렬구유궤체보호성적Ⅱ상해독매화항양화매기인급단백득이표체，주요포괄과양화경매（CAT）、초양화물기화매（SOD）、곤양화환원매1（NQO1）이급혈홍소가양매1（HO-1）。저사피격활적보호성매류능구삼여체내적엄범조절작용，대인체진행다방면적보호，연구발현해통로여궤체염증、종류、쇠로、조망、신경손상、생육、부산과질병등다방면균유밀절련계。종술Nrf2-ARE신호통로공능적연구진전，지재전면객관지인식기생리공능。
Nuclear factor E2 related factor 2 (Nrf2) is a pivotal regulator of antioxidative stress. Under normal condition, its degradation is mediated in the cytoplasm and therefore don′t exert physiologic function. When it was been activated by detrimental assault,Nrf2 can translocate into nuclear to bind with the antioxidant response element (ARE) then to form the Nrf2-ARE signal pathway,which subsequently activates a series of protective genes and proteins including catalase (CAT),superoxide dismutase (SOD),NAD (P)H:quinine oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1). These enzymes play an important role in protecting somatic cells from detrimental assault. Researches have demonstrated that the pathway is associated with inflammation,tumor,aging,apoptosis,nervous injury and fertility as well as obstetrical and gynecological diseases closely. In order to understand the physiologic function of the pathway comprehensively ,the present review is proposed.