中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2015年
7期
607-610
,共4页
杨志林%徐晓丹%肖福银%邹枝玲
楊誌林%徐曉丹%肖福銀%鄒枝玲
양지림%서효단%초복은%추지령
药物渴求%特质冲动性%状态冲动性%成瘾严重程度
藥物渴求%特質遲動性%狀態遲動性%成癮嚴重程度
약물갈구%특질충동성%상태충동성%성은엄중정도
Drug craving%Trait impulsivity%State impulsivity%Drug dependence severity
目的 探讨药物依赖者的冲动性与渴求之间的关系是否受到成瘾严重程度的影响.方法 采用成瘾严重程度指数量表(addiction severity index,ASI)评估被试的成瘾严重程度,将36名药物依赖者分为高成瘾组和低成瘾组,采用Barratt冲动性量表(Barratt impulsiveness scale,BIS-11)和经典Stroop色词任务分别测量被试的特质冲动性和状态冲动性,采用block设计的线索反应范式评估被试的渴求水平,然后对比高、低成瘾组被试的冲动性与渴求之间的关系.结果 对高成瘾组被试,无论特质冲动性[BIS-11-CI分数为(39.03±16.50)分]还是状态冲动性[Stroop任务中一致条件与不一致条件下的反应时差异的平均值为(87.77±36.95) ms]均与其渴求评分[(0.83±1.91)分]呈显著正相关(Person相关系数分别为0.487,0.500,P＜0.05);但是对低成瘾组被试,冲动性与渴求之间的相关不显著(相关系数分别为-0.261,0.081,P＞0.05).结论 药物依赖者的冲动性(包括特质冲动性与状态冲动性)与渴求之间的关系受到成瘾严重程度的影响,将冲动性作为渴求水平的预测指标只能针对高成瘾组被试.该结果提示,长期的物质依赖造成的大脑功能的损害可能涉及冲动性和渴求的共同机制.
目的 探討藥物依賴者的遲動性與渴求之間的關繫是否受到成癮嚴重程度的影響.方法 採用成癮嚴重程度指數量錶(addiction severity index,ASI)評估被試的成癮嚴重程度,將36名藥物依賴者分為高成癮組和低成癮組,採用Barratt遲動性量錶(Barratt impulsiveness scale,BIS-11)和經典Stroop色詞任務分彆測量被試的特質遲動性和狀態遲動性,採用block設計的線索反應範式評估被試的渴求水平,然後對比高、低成癮組被試的遲動性與渴求之間的關繫.結果 對高成癮組被試,無論特質遲動性[BIS-11-CI分數為(39.03±16.50)分]還是狀態遲動性[Stroop任務中一緻條件與不一緻條件下的反應時差異的平均值為(87.77±36.95) ms]均與其渴求評分[(0.83±1.91)分]呈顯著正相關(Person相關繫數分彆為0.487,0.500,P＜0.05);但是對低成癮組被試,遲動性與渴求之間的相關不顯著(相關繫數分彆為-0.261,0.081,P＞0.05).結論 藥物依賴者的遲動性(包括特質遲動性與狀態遲動性)與渴求之間的關繫受到成癮嚴重程度的影響,將遲動性作為渴求水平的預測指標隻能針對高成癮組被試.該結果提示,長期的物質依賴造成的大腦功能的損害可能涉及遲動性和渴求的共同機製.
목적 탐토약물의뢰자적충동성여갈구지간적관계시부수도성은엄중정도적영향.방법 채용성은엄중정도지수량표(addiction severity index,ASI)평고피시적성은엄중정도,장36명약물의뢰자분위고성은조화저성은조,채용Barratt충동성량표(Barratt impulsiveness scale,BIS-11)화경전Stroop색사임무분별측량피시적특질충동성화상태충동성,채용block설계적선색반응범식평고피시적갈구수평,연후대비고、저성은조피시적충동성여갈구지간적관계.결과 대고성은조피시,무론특질충동성[BIS-11-CI분수위(39.03±16.50)분]환시상태충동성[Stroop임무중일치조건여불일치조건하적반응시차이적평균치위(87.77±36.95) ms]균여기갈구평분[(0.83±1.91)분]정현저정상관(Person상관계수분별위0.487,0.500,P＜0.05);단시대저성은조피시,충동성여갈구지간적상관불현저(상관계수분별위-0.261,0.081,P＞0.05).결론 약물의뢰자적충동성(포괄특질충동성여상태충동성)여갈구지간적관계수도성은엄중정도적영향,장충동성작위갈구수평적예측지표지능침대고성은조피시.해결과제시,장기적물질의뢰조성적대뇌공능적손해가능섭급충동성화갈구적공동궤제.
Objective To investigate the effect of drug dependence severity on the relationship between impulsivity and craving.Methods 36 abstiuent drug-dependent individuals were recruited in the study.The participants were divided into the heavy depeudence group (HDG) or the low dependence group (LDG) according to the scores of Addiction Severity Index (ASI).The Barratt Impulsiveness Scale (BIS-11) and classical Stroop task were used to measure the trait impulsivity and state impulsivity.Block designed cue-induced craving paradigm was presented to measure cue-elicited craving.Results For the HDG,a significant positive correlation was found between trait impulsivity (the mean value of BIS-11-CI scale was (39.03± 16.50)) or state impulsivity (the difference of reaction time between congruent and incongruent situation was (87.77±36.95)ms)and cue-elicited craving (0.83± 1.91)(r=0.487,0.500,P＜0.05).However,for the LDG subjects,the impulsivity was not found significantly correlated with the cue-elicited craving(r=-0.261,0.081,P＞0.05).Conclusion The addiction severity influences the relationship between impulsivity and craving,and impulsivity can only be used as a predictor of relapse in HDG.The findings suggest that the drug may influence the shared brain mechanism between impulsivity and craving.
