CAJ | 학술논문

目的探讨老年男性冠心病患者的性激素的变化、抑郁状态与冠心病的发生及冠脉病变严重程度的相关性.方法单纯随机抽样法选取心内科住院的300例老年男性作为研究对象,根据有无冠心病,分为冠心病组(220例)和对照组(80例).入院后先进行汉密顿抑郁量表(HAMD24版本)评分,并检测患者血清睾酮及雌二醇水平,造影后进行冠状动脉的Gensini评分.通过多元线性回归分析患者冠脉Gensini评分、汉密顿抑郁量表评分及血清睾酮、雌二醇水平之间的相关性.结果 (1)冠心病组HAMD评分高于非冠心病组[分别为(23.82± 11.74)分,(21.25±10.54)分],冠心病组血清T水平低于非冠心病组[分别为(11.23±4.46) ng/ml,(15.96±5.87) ng/ml],差异有统计学意义(P＜0.05).(2)睾酮与HAMD评分呈负相关(t=-3.562,P＜0.05),R2=0.041,F=12.960(P＜0.01).(3)睾酮与Gensini评分呈负相关(t=-4.276,P＜0.01),R2=0.058,F=18.286(P＜0.01).(4)雌二醇血清含量与HAMD评分无相关;(5)Genisini 评分与HAMD评分呈正相关(t=-3.977 P＜0.01),R2=0.045,F=14.175(P＜0.01).结论男性血清睾酮水平与冠状动脉病变程度、抑郁水平呈负相关;冠心病患者其冠脉病变程度与抑郁症的抑郁水平呈正相关.
목적 탐토노년남성관심병환자적성격소적변화、억욱상태여관심병적발생급관맥병변엄중정도적상관성.방법 단순수궤추양법선취심내과주원적300례노년남성작위연구대상,근거유무관심병,분위관심병조(220례)화대조조(80례).입원후선진행한밀돈억욱량표(HAMD24판본)평분,병검측환자혈청고동급자이순수평,조영후진행관상동맥적Gensini평분.통과다원선성회귀분석환자관맥Gensini평분、한밀돈억욱량표평분급혈청고동、자이순수평지간적상관성.결과 (1)관심병조HAMD평분고우비관심병조[분별위(23.82± 11.74)분,(21.25±10.54)분],관심병조혈청T수평저우비관심병조[분별위(11.23±4.46) ng/ml,(15.96±5.87) ng/ml],차이유통계학의의(P＜0.05).(2)고동여HAMD평분정부상관(t=-3.562,P＜0.05),R2=0.041,F=12.960(P＜0.01).(3)고동여Gensini평분정부상관(t=-4.276,P＜0.01),R2=0.058,F=18.286(P＜0.01).(4)자이순혈청함량여HAMD평분무상관;(5)Genisini 평분여HAMD평분정정상관(t=-3.977 P＜0.01),R2=0.045,F=14.175(P＜0.01).결론 남성혈청고동수평여관상동맥병변정도、억욱수평정부상관;관심병환자기관맥병변정도여억욱증적억욱수평정정상관.
Objective To reveal the relevance of the elderly male sex hormone changes and the occurrence of depression in the elderly,severity of coronary artery disease occurrence and sex hormoue levels,depression status and coronary heart disease(CHD) in coronary heart disease patients.Methods Total of 300 elderly male patients underwent coronary angiography in the department of cardiology were collected,including 80 controls and 220 coronary heart disease patients.All coronary angiography elderly male patients admitted to hospital were analyzed by Hamilton Depression Scale (HAMD24 version),the patient's serum testosterone,estradiol levels and Gensini score of coronary after angiography were checked.The multiple linear regression analysis was used to investigate the correlation amoug coronary Gensini score,Hamilton Depression Scale score and serum testosterone.Results (1) The HAMD scores in CHD group were higher than those in controls ((23.82±11.74) vs (21.25±10.54)),and testosterone level was lower than that in controls ((11.23 ± 4.46) ng/ml,(15.96 ± 5.87) ng/ml,respectively),the difference was statistically significant (P＜0.05).(2)Testosterone and HAMD score was negatively correlated (t=-3.562,P＜0.05),and the correlation coefficient (R 2) was 0.041,F value was 12.960 (P＜0.01).(3) Testosterone and HAMD score was negatively correlated (t=-4.276,P＜0.05),and the correlation coefficient (R 2) was 0.058,F value was 18.286 (P＜0.01).(4)Estradiol serum content and HAMD score showed no correlation.(5)Genisini scores were positively correlated with HAMD score (t=-3.977,P＜0.05),the correlation coefficient (R 2) was 0.045,F value was 14.175 (P＜0.01).Conclusion Serum testosterone levels of the men are negatively correlated with coronary artery disease and depression levels.The degree of coronary artery lesions in patients with coronary heart disease was positively correlated with depression level of depression.