CAJ | 학술논문

目的探究抑郁症患者在处理情绪刺激时,脑岛与腹侧系统脑区之间的效能连接情况及其与临床相关性.方法选取27例抑郁症患者和27例健康对照者进行脑磁图扫描,选取悲伤表情刺激下的脑磁信号.选取的感兴趣脑区包括脑岛、杏仁核、前扣带回、眶额回和腹内侧前额叶.应用SPM8软件进行数据预处理及源重建,提取感兴趣时间窗0～ 600 ms时间序列,进行主成分方法降维,利用格兰杰因果模型进一步计算效能连接值.结果抑郁症患者眶额回到前扣带回效能连接增强(P=0.016),脑岛到腹内侧前额叶(P=0.022),及前扣带回到脑岛的效能连接(P=0.006)均较健康对照者增强,差异具有统计学意义.前扣带回到脑岛的效能连接与临床有效病程呈正相关(r=0.392,P＜0.05).结论抑郁症在处理负性情绪刺激时,脑岛与前扣带回及腹内侧前额叶脑区效能连接增强,提示对负性刺激处理增强.本研究结果提示脑岛不仅在抑郁症患者静息态中起着重要作用,且在处理情绪任务中也起着重要作用.
목적 탐구억욱증환자재처리정서자격시,뇌도여복측계통뇌구지간적효능련접정황급기여림상상관성.방법 선취27례억욱증환자화27례건강대조자진행뇌자도소묘,선취비상표정자격하적뇌자신호.선취적감흥취뇌구포괄뇌도、행인핵、전구대회、광액회화복내측전액협.응용SPM8연건진행수거예처리급원중건,제취감흥취시간창0～ 600 ms시간서렬,진행주성분방법강유,이용격란걸인과모형진일보계산효능련접치.결과 억욱증환자광액회도전구대회효능련접증강(P=0.016),뇌도도복내측전액협(P=0.022),급전구대회도뇌도적효능련접(P=0.006)균교건강대조자증강,차이구유통계학의의.전구대회도뇌도적효능련접여림상유효병정정정상관(r=0.392,P＜0.05).결론 억욱증재처리부성정서자격시,뇌도여전구대회급복내측전액협뇌구효능련접증강,제시대부성자격처리증강.본연구결과제시뇌도불부재억욱증환자정식태중기착중요작용,차재처리정서임무중야기착중요작용.
Objective To investigate the functional connectivity of the insula with ventral neural system and the relationship with the clinical feature during emotion processing in major depressive disorder.Methods Twenty-seven patients with major depressive disorder(MDD) and well-matched healthy controls were enrolled in this study.They were asked to recognize the facial emotion during magnetoencephalograph (MEG) scanning.Then the magnetic signals of the sad face was extracted and further processed with the software of SPM8,with the interested regions including the amygdala (AMYG),the insula,the anterior cingulate cortex (ACC),the orbitofrontal cortex (OFC) and the ventromedial prefrontal cortex (VMPFC).The interested time series were selected between 0-600 ms,which was analyzed by the method of principal component analysis (PCA) to reduce the differences.The next step was to compute the effective connectivity of the interested brain areas with the approach of ganger causality model(GCM).Results The effective connectivity from the OFC to the ACC was obviously enhanced in MDD(P=0.016),in addition with the connectivity from the insula to the VMPFC(P=0.022) and the ACC(P=0.006) to the insula.Furthermore,the value of the connectivity from the anterior cingulate cortex to the insula was positively correlated with the illness duration(r=0.392,P＜0.05).Conclusions The enhanced connectivity of the increased communieation between them,indicating the enhancement of the processing of sad stimuli.Our results indicate that the insula plays a pivotal role,not only in the resting-sate,but also in the emotion processing task.