中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2015年
7期
665-668
,共4页
熊北斗%刘想想%吴欣圆%李科%毕勇毅
熊北鬥%劉想想%吳訢圓%李科%畢勇毅
웅북두%류상상%오흔원%리과%필용의
电子香烟%戒烟%安全性%Meta分析
電子香煙%戒煙%安全性%Meta分析
전자향연%계연%안전성%Meta분석
Electronic cigarette%Smoking cessation%Adversity%Meta-analysis
目的 电子香烟对戒烟的作用及对人类健康安全性尚无定论,且当前关于电子香烟的研究较少,故采用Meta分析的方法对这一问题做出评价以期对解决这一问题提供一些帮助.方法 计算机检索PubMed、Medline、Embase、Cochrane library、中国知网(CNKI)和万方数据库,查找2014年5月前发表的研究电子香烟与戒烟关系或者健康安全性的文献.由2名评价者独立选择试验、提取资料和评估文献质量后,采用RevMan 5.1软件进行Meta分析,采用随机或者固定效应模型来合并RR值.结果 4篇文章纳入该Meta分析,共计7 002个研究对象.Meta分析结果显示电子香烟对于吸烟者减少吸烟RR=1.88,95％ CI:1.07～3.32,P=0.09,差异无统计学意义.电子香烟对戒烟影响RR=1.55,95％ CI:1.24～ 1.95,P=0.001提示结果有统计学意义.结论 本Meta分析显示,电子香烟对于吸烟者减少传统香烟使用量效果差异无统计学意义,对戒烟有效性差异有统计学意义.但本Meta分析纳入文献数量较少,且文献之间存在异质性,故上述结论仍需要高质量的大样本随饥盲法试验来验证.
目的 電子香煙對戒煙的作用及對人類健康安全性尚無定論,且噹前關于電子香煙的研究較少,故採用Meta分析的方法對這一問題做齣評價以期對解決這一問題提供一些幫助.方法 計算機檢索PubMed、Medline、Embase、Cochrane library、中國知網(CNKI)和萬方數據庫,查找2014年5月前髮錶的研究電子香煙與戒煙關繫或者健康安全性的文獻.由2名評價者獨立選擇試驗、提取資料和評估文獻質量後,採用RevMan 5.1軟件進行Meta分析,採用隨機或者固定效應模型來閤併RR值.結果 4篇文章納入該Meta分析,共計7 002箇研究對象.Meta分析結果顯示電子香煙對于吸煙者減少吸煙RR=1.88,95％ CI:1.07～3.32,P=0.09,差異無統計學意義.電子香煙對戒煙影響RR=1.55,95％ CI:1.24～ 1.95,P=0.001提示結果有統計學意義.結論 本Meta分析顯示,電子香煙對于吸煙者減少傳統香煙使用量效果差異無統計學意義,對戒煙有效性差異有統計學意義.但本Meta分析納入文獻數量較少,且文獻之間存在異質性,故上述結論仍需要高質量的大樣本隨饑盲法試驗來驗證.
목적 전자향연대계연적작용급대인류건강안전성상무정론,차당전관우전자향연적연구교소,고채용Meta분석적방법대저일문제주출평개이기대해결저일문제제공일사방조.방법 계산궤검색PubMed、Medline、Embase、Cochrane library、중국지망(CNKI)화만방수거고,사조2014년5월전발표적연구전자향연여계연관계혹자건강안전성적문헌.유2명평개자독립선택시험、제취자료화평고문헌질량후,채용RevMan 5.1연건진행Meta분석,채용수궤혹자고정효응모형래합병RR치.결과 4편문장납입해Meta분석,공계7 002개연구대상.Meta분석결과현시전자향연대우흡연자감소흡연RR=1.88,95％ CI:1.07～3.32,P=0.09,차이무통계학의의.전자향연대계연영향RR=1.55,95％ CI:1.24～ 1.95,P=0.001제시결과유통계학의의.결론 본Meta분석현시,전자향연대우흡연자감소전통향연사용량효과차이무통계학의의,대계연유효성차이유통계학의의.단본Meta분석납입문헌수량교소,차문헌지간존재이질성,고상술결론잉수요고질량적대양본수기맹법시험래험증.
Objective The effect of electronic cigarettes (e-cigarettes) on smoking reduction,cessation and human health remains controversial,meanwhile,studies tocused on e-cigarettes are limited.We conducted this meta-analysis in purpose of helping figuring out the controversy.Methods PubMed, Medline,Embase,Cochrane library,CNKl and Wanfang Databases were searched for articles published up to May 2014.All studies discussing the relationship between e-cigarettes and smoking reduction,smoking cessation or human health were included.The fixed or random-eftect model was used to pool the relative risk(RR).Outcome 4 articles were included based on the inclusion and exclusion criteria,there were totally 7 002 subjects.Meta-analysis indicated that there was significant difference in e-cigarettes and smoking reduction,RR=1.88,95％ CI:1.07-3.32,P=0.09.The Meta-analysis showed that e-cigarettes were available in smoking cessation.RR=1.55,95％ CI:1.24-1.95,P=0.001.Conclusion Tiffs meta-analysis indicated that e-cigarettes were helpful in smoking cessation.Nonetheless,the articles included were too few to credibly support the outcome.Hence,more high-quality,randomized blind and large sample experiments are needed to verify the results.
