CAJ | 학술논문

目的：调查不同人群中新型呼肠病毒既往感染情况。方法选取健康人群以及手足口病、腹泻、麻疹、乙型肝炎等患者的血清标本，利用微量中和试验检测其血清标本中新型呼肠病毒IgG抗体。结果中和试验结果表明，健康人群中新型呼肠病毒IgG抗体阳性率为29.90%，抗体滴度的中位数为1∶32；手足口病患者中抗体阳性率为70.83%，抗体滴度的中位数为1∶64；乙型肝炎和麻疹患者抗体阳性率分别为90.22%和90.70%，抗体滴度的中位数均为1∶128；腹泻患者中抗体阳性率和抗体滴度的中位数均最高，分别为100%和1∶256。结论健康人群与不同疾病患者中新型呼肠病毒特异性IgG抗体阳性率及滴度存在显著差异。
목적：조사불동인군중신형호장병독기왕감염정황。방법선취건강인군이급수족구병、복사、마진、을형간염등환자적혈청표본，이용미량중화시험검측기혈청표본중신형호장병독IgG항체。결과중화시험결과표명，건강인군중신형호장병독IgG항체양성솔위29.90%，항체적도적중위수위1∶32；수족구병환자중항체양성솔위70.83%，항체적도적중위수위1∶64；을형간염화마진환자항체양성솔분별위90.22%화90.70%，항체적도적중위수균위1∶128；복사환자중항체양성솔화항체적도적중위수균최고，분별위100%화1∶256。결론건강인군여불동질병환자중신형호장병독특이성IgG항체양성솔급적도존재현저차이。
Objective To evaluate the prevalence of past infection with a novel reovirus in different populations. Methods The serum samples were taken from 97 healthy people and 219 patients with hand, foot and mouth disease (HFMD), diarrhea, measles and hepatitis B treated in our hospital. The prevalence of the novel reovirus-specific IgG antibody in sera was detected by using a neutraliza-tion assay. Results The neutralization assay demonstrated that the positive rates of the novel reovirus-specific IgG antibody were 29.90%in healthy controls, 70.83%in HFMD group, 90.22%in hepatitis B group, 90.70%in measles group and 100%in diarrhea group, and the median IgG antibody titers were 1∶32, 1∶64, 1∶128, 1∶128 and 1∶256 in those groups respectively. Conclusions The positive rates and titers of a novel reovirus-specific IgG antibody are significantly different between the healthy population and patients with different diseases.