CAJ | 학술논문

宫颈癌严重危害女性健康，现已明确人乳头瘤病毒（HPV）感染是其主要致病因素。HPV通过机体的细微损伤入侵，HPV E6和E7癌蛋白中的1种或2种持续表达是高危型HPV感染致瘤的关键所在，检测高危型HPV感染及病毒癌蛋白仍不能有效预防宫颈癌。研究者们正着手研制针对HPV的病毒疫苗，从源头预防HPV感染，以期实现宫颈癌的一级预防。目前已有针对HPV16/18型的二价疫苗Cervarix和针对HPV16/18/11/6型的四价疫苗Gardasil的认证上市，预防性HPV疫苗已在全球范围内推广使用并取得显著效果。新一代预防性HPV疫苗在解决疫苗的成本、持久性和广谱免疫问题上取得突破性进展，宫颈癌有望成为人类抗肿瘤史上第一个可以预防的癌症。综述近年HPV的生物学特性、致病机制及预防性HPV疫苗的应用研究与现状。
궁경암엄중위해녀성건강，현이명학인유두류병독（HPV）감염시기주요치병인소。HPV통과궤체적세미손상입침，HPV E6화E7암단백중적1충혹2충지속표체시고위형HPV감염치류적관건소재，검측고위형HPV감염급병독암단백잉불능유효예방궁경암。연구자문정착수연제침대HPV적병독역묘，종원두예방HPV감염，이기실현궁경암적일급예방。목전이유침대HPV16/18형적이개역묘Cervarix화침대HPV16/18/11/6형적사개역묘Gardasil적인증상시，예방성HPV역묘이재전구범위내추엄사용병취득현저효과。신일대예방성HPV역묘재해결역묘적성본、지구성화엄보면역문제상취득돌파성진전，궁경암유망성위인류항종류사상제일개가이예방적암증。종술근년HPV적생물학특성、치병궤제급예방성HPV역묘적응용연구여현상。
Cervical cancer causes serious damage to women′s health. It is clear that human papillomavirus (HPV) infection is the major pathogenic factor. HPV invades the organism by subtle injures. When E6 or E7 oncoprotein is continous expression in the epithelial tissue, high-risk HPV infections contribute to tumorigenicity. Detection of high-risk HPV infection and virus oncoprotein still cannot prevent cervical cancer effectively. Researchers begin to develop a vaccine against the HPV virus, and to prevent HPV infections from the sources, hoping to achieve the primary prevention of cervical cancer. Currently bivalent vaccine Cervarix against HPV 16/18 and quadrivalent vaccine Gardasil against HPV 16/18/11/16 have been approved for marketing. Prophylactic HPV vaccines have been used widely on a global scale and obtained significant effect. A new generation of prophylactic HPV vaccines have made a breakthrough in solving problems including cost, persistence and broad-spectrum immune. Cervical cancer is expected to become the first preventable cancer in the history of human anti-tumor. This review concentrates on the biological characteristics and pathogenic mechanism of HPV and the current application and situation of prophylactic HPV vaccines.