CAJ | 학술논문

妊娠期高血压疾病（HDCP）是一种较为常见的严重危害母婴健康的妊娠期特有疾病，其病因及发病机制尚不明确。 HDCP主要病理生理是全身小动脉痉挛，内皮损伤和局部缺血。血清尿酸（UA）是人类嘌呤代谢的最终产物，主要由肾脏排泄。研究证实，HDCP与血清UA关系密切，且两者相互作用、相互影响。监测血清UA对于评估HDCP尤其是子痫前期的发生与发展可能具有重要意义。但临床上应用血清UA水平预测或早期诊断子痫前期仍存在争议；联合多种检测指标，构建新的检测模型，是否可有效提高预测价值，目前尚未明确。主要围绕HDCP的基本病理生理与血清UA代谢的相互影响，血清UA与子痫前期发病的密切关系，血清UA对子痫前期临床诊断、母儿预后的预测价值等方面进行综述。
임신기고혈압질병（HDCP）시일충교위상견적엄중위해모영건강적임신기특유질병，기병인급발병궤제상불명학。 HDCP주요병리생리시전신소동맥경련，내피손상화국부결혈。혈청뇨산（UA）시인류표령대사적최종산물，주요유신장배설。연구증실，HDCP여혈청UA관계밀절，차량자상호작용、상호영향。감측혈청UA대우평고HDCP우기시자간전기적발생여발전가능구유중요의의。단림상상응용혈청UA수평예측혹조기진단자간전기잉존재쟁의；연합다충검측지표，구건신적검측모형，시부가유효제고예측개치，목전상미명학。주요위요HDCP적기본병리생리여혈청UA대사적상호영향，혈청UA여자간전기발병적밀절관계，혈청UA대자간전기림상진단、모인예후적예측개치등방면진행종술。
Hypertensive disorders complicating pregnancy (HDCP) is a common clinical disease specially correlated to pregnancy,which had serious harm on maternal and child health. The etiology and pathogenesis mechanism of HDCP is not yet entirely clear. The main pathophysiological change of HDCP is systemic small vessel spasm ,endothelial injury and local ischemia. Serum uric acid (UA) is the end product of purine metabolism in human,which is mainly excreted by kidney. Previous studies confirmed that the relationship between HDCP and serum UA was extremely close ,and they had both interaction and influence to each other. It might have an important significance to monitor serum UA level for assessment of the occurrence and development of HDCP,especially preeclampsia. However,there is still no small controversy on the clinical application of serum UA level for the prediction or early diagnosis of preeclampsia. It is not clear whether the predictive value could be effectively improved by combination with a variety of detection indexes and construction of a new detection model. A summarization will be established in this paper on the issues as follows: the basic pathophysiology of HDCP,and the interaction between HDCP and serum UA metabolism. The close relationship between serum UA and the pathogenesis of preeclampsia. The predictive value of serum UA on the clinical diagnosis along with the prognosis of mother and fetus in preeclampsia.