CAJ | 학술논문

目的：探讨静脉注射维生素 C 对透析后肾性贫血的治疗效果。方法将80例接受透析治疗的肾性贫血患者依据数字表法随机分为研究组和对照组，每组40例。两组患者均给予皮下注射重组人红细胞生成素（EPO）和蔗糖铁静脉滴注，研究组在此基础上加用维生素 C 静脉推注治疗。对比两组患者血红蛋白（Hb）、血红细胞指标、铁代谢相关指标及不良反应。结果研究组患者治疗后各时段 Hb、红细胞比容（Hct）、红细胞数量（RBC）和未溶解红细胞比例（RBC%）均显著高于对照组和治疗前，且差异有统计学意义（P ﹤0.05）。同时研究组患者治疗后各时段的血清铁（SI）、血清铁蛋白（SF）、转铁蛋白饱和度（TSAT）均显著高于治疗前和对照组，且差异有统计学意义（P ﹤0.05）。两组患者不良反应的差异无统计学意义（P ﹥0.05）。结论透析时静脉推注维生素 C 可以有效改善肾性贫血患者的贫血症状和铁代谢。
목적：탐토정맥주사유생소 C 대투석후신성빈혈적치료효과。방법장80례접수투석치료적신성빈혈환자의거수자표법수궤분위연구조화대조조，매조40례。량조환자균급여피하주사중조인홍세포생성소（EPO）화자당철정맥적주，연구조재차기출상가용유생소 C 정맥추주치료。대비량조환자혈홍단백（Hb）、혈홍세포지표、철대사상관지표급불량반응。결과연구조환자치료후각시단 Hb、홍세포비용（Hct）、홍세포수량（RBC）화미용해홍세포비례（RBC%）균현저고우대조조화치료전，차차이유통계학의의（P ﹤0.05）。동시연구조환자치료후각시단적혈청철（SI）、혈청철단백（SF）、전철단백포화도（TSAT）균현저고우치료전화대조조，차차이유통계학의의（P ﹤0.05）。량조환자불량반응적차이무통계학의의（P ﹥0.05）。결론투석시정맥추주유생소 C 가이유효개선신성빈혈환자적빈혈증상화철대사。
Objective To study the clinical efficacy of vitamin C injection in the treatment of renal anemia after dialysis. Methods A total of 80 patients with renal anemia were randomly divided into study group and control group according to random number tables,with 40 patients in each group. All the patients were treated with EPO subcutaneous injection,iron sucrose intravenous drip and dialysis. Addi-tionally,patients in the study group were treated with vitamin C injection. The hemoglobin level,red blood cell indexes,iron metabolism in-dexes and adverse reaction between the two groups were compared. Results After treatment,the hemoglobin level,RBC count and hemato-crit in the study group were significantly higher than those in the control group and before treatment(P ﹤ 0. 05),the blood SI,SF,TSAT in the study group were also significantly higher than those in the control group and before treatment(P ﹤ 0. 05). There was no significant difference of adverse reaction between the two groups(P ﹥ 0. 05). Conclusion The therapy of vitamin C injection during dialysis has better clinical efficacy on renal anemia,which can relieve anemia symptom and improve iron metabolism.