安徽医学
安徽醫學
안휘의학
ANHUI MEDICAL JOURNAL
2015年
8期
927-930
,共4页
徐娟%徐福霞%李杰%程忠玉%赵国霞
徐娟%徐福霞%李傑%程忠玉%趙國霞
서연%서복하%리걸%정충옥%조국하
宫外孕%孕酮%CA125%β-HCG
宮外孕%孕酮%CA125%β-HCG
궁외잉%잉동%CA125%β-HCG
Ectopic pregnancy%Progesterone%CA125%β-HCG
目的：探讨孕妇血清孕酮、CA125及β-HCG 水平单独及联合检测在宫外孕诊断中的价值。方法选择2013年6月至2014年10月安徽省第二人民医院妇产科收治入院的宫外孕患者和同期就诊的正常早孕女性作为研究对象，其中宫外孕组39例，正常早孕组30例，所有患者均行血清孕酮、CA125含量检测及β-HCG 48 h 增长率计算。比较分析以上3个指标在两组受检者中的差异，并通过回顾性分析，研究影响孕酮、CA125水平和β-HCG 48 h 增长率检测的因素及对3项指标联合检测在宫外孕诊断中的特异性、灵敏性进行分析比较。结果①宫外孕组患者血清孕酮、CA125水平及β-HCG 48 h 增长率检测结果分别是：（9.28±3.34）ng/ mL，（19.74±14.17）U/ mL，（22.25±13.63）%，而在正常早孕组分别是：（25.90±11.94）ng/ mL，（72.36±25.99）U/mL，（101.85±27.49）%。宫外孕受检者血清孕酮、CA125水平及β-HCG 48 h 增长率均较正常早孕者低，差异有统计学意义（P ﹤0.05）。ROC 分析提示3项指标均可应用于宫外孕的诊断，其中以β-HCG 48 h 增长率测定诊断价值最高。②回顾性研究发现，血清孕酮、CA125水平、β-HCG 48 h 增长率及3项指标联合检测宫外孕诊断灵敏度分别为：71.8%，74.4%，87.2%，98.5%；特异度分别为：70%，96.7%，86.7%，90.5%。结论无论是血清孕酮、CA125水平及β-HCG 48 h 增长率各单项指标检测还是联合测定，对宫外孕均有重要辅助诊断价值，但联合检测的诊断价值要优于任一单项血清指标。
目的：探討孕婦血清孕酮、CA125及β-HCG 水平單獨及聯閤檢測在宮外孕診斷中的價值。方法選擇2013年6月至2014年10月安徽省第二人民醫院婦產科收治入院的宮外孕患者和同期就診的正常早孕女性作為研究對象，其中宮外孕組39例，正常早孕組30例，所有患者均行血清孕酮、CA125含量檢測及β-HCG 48 h 增長率計算。比較分析以上3箇指標在兩組受檢者中的差異，併通過迴顧性分析，研究影響孕酮、CA125水平和β-HCG 48 h 增長率檢測的因素及對3項指標聯閤檢測在宮外孕診斷中的特異性、靈敏性進行分析比較。結果①宮外孕組患者血清孕酮、CA125水平及β-HCG 48 h 增長率檢測結果分彆是：（9.28±3.34）ng/ mL，（19.74±14.17）U/ mL，（22.25±13.63）%，而在正常早孕組分彆是：（25.90±11.94）ng/ mL，（72.36±25.99）U/mL，（101.85±27.49）%。宮外孕受檢者血清孕酮、CA125水平及β-HCG 48 h 增長率均較正常早孕者低，差異有統計學意義（P ﹤0.05）。ROC 分析提示3項指標均可應用于宮外孕的診斷，其中以β-HCG 48 h 增長率測定診斷價值最高。②迴顧性研究髮現，血清孕酮、CA125水平、β-HCG 48 h 增長率及3項指標聯閤檢測宮外孕診斷靈敏度分彆為：71.8%，74.4%，87.2%，98.5%；特異度分彆為：70%，96.7%，86.7%，90.5%。結論無論是血清孕酮、CA125水平及β-HCG 48 h 增長率各單項指標檢測還是聯閤測定，對宮外孕均有重要輔助診斷價值，但聯閤檢測的診斷價值要優于任一單項血清指標。
목적：탐토잉부혈청잉동、CA125급β-HCG 수평단독급연합검측재궁외잉진단중적개치。방법선택2013년6월지2014년10월안휘성제이인민의원부산과수치입원적궁외잉환자화동기취진적정상조잉녀성작위연구대상，기중궁외잉조39례，정상조잉조30례，소유환자균행혈청잉동、CA125함량검측급β-HCG 48 h 증장솔계산。비교분석이상3개지표재량조수검자중적차이，병통과회고성분석，연구영향잉동、CA125수평화β-HCG 48 h 증장솔검측적인소급대3항지표연합검측재궁외잉진단중적특이성、령민성진행분석비교。결과①궁외잉조환자혈청잉동、CA125수평급β-HCG 48 h 증장솔검측결과분별시：（9.28±3.34）ng/ mL，（19.74±14.17）U/ mL，（22.25±13.63）%，이재정상조잉조분별시：（25.90±11.94）ng/ mL，（72.36±25.99）U/mL，（101.85±27.49）%。궁외잉수검자혈청잉동、CA125수평급β-HCG 48 h 증장솔균교정상조잉자저，차이유통계학의의（P ﹤0.05）。ROC 분석제시3항지표균가응용우궁외잉적진단，기중이β-HCG 48 h 증장솔측정진단개치최고。②회고성연구발현，혈청잉동、CA125수평、β-HCG 48 h 증장솔급3항지표연합검측궁외잉진단령민도분별위：71.8%，74.4%，87.2%，98.5%；특이도분별위：70%，96.7%，86.7%，90.5%。결론무론시혈청잉동、CA125수평급β-HCG 48 h 증장솔각단항지표검측환시연합측정，대궁외잉균유중요보조진단개치，단연합검측적진단개치요우우임일단항혈청지표。
Objective To investigate the diagnosticvalue of singleor combined measurement of serum progesterone,CA125 and β-HCG levelsin ectopic pregnancy. Methods 39 cases of exfetation patients hospitalized in our departmentfrom Oct 2013 to Jun 2014and 30 cases ofearly pregnancy outpatientswere enrolledas subjects. The serum progesteroneand CA125 levels and the growth rate of β-HCG within 48 hours were measured in all the patients,andthe differences of these three indexes between the two groupswere compared for significance. The affected factors and the specificity and sensitivity of combined measurement of these threeindexes in the diagnosis of ectopic pregnancy were investigated by a retrospective study. Results The respective mean values of serum progesterone and CA125 levelsand growthrate ofβ-HCG-within 48hoursin the ectopic pregnancy group were(9. 28 ± 3. 34)ng/ mL,(19. 74 ± 14. 17)U/ mL and(22. 25 ± 13. 63)% ,whereas the mean values of theindexes above in the early pregnancy group were(25. 90 ± 11. 94)ng/ mL,(72. 36 ± 25. 99)U/ mL and(101. 85 ± 27. 49)% ,respectively. The values of these threeindexesin the ectopic pregnancy group were much lower than those in the early pregnancy group,and the differencesbetween themwere statistically significant(P ﹤ 0. 05). Results of ROC analysis indicated that,all the three indexes can be applied to diagnosis ectopic pregnancy,but the diagnostic value of growthrate ofβ-HCGwithin 48hours was highest. As aretrospective study showed,the respectivesensitivity of singleor combined measurement of serum progesterone,CA125 and β-HCG levels were 71. 8% ,74. 4% ,87. 2% and 98. 5% ,and the specificity of singleor combined measurementwere 70% ,96. 7% ,86. 7% and 90. 5% ,respectively. Conclusion Both the singleindexofserum progesterone and CA125 levelsand growthrate ofβ-HCGwithin 48hours and the combined measure-ment of these indexeshave predictive value for exfetation,but the latter is more accurateandeffective than any of the single index.
