CAJ | 학술논문

目的：检测幽门螺杆菌（HP）感染患者血清中胃泌素-17（G-17）、胃蛋白酶原Ⅰ（PG-Ⅰ）和胃蛋白酶原Ⅱ（PG-Ⅱ）的含量，探讨其与 HP 感染发生的相关性。方法用 ELISA 法分别定量检测 HP 感染阳性组和 HP 感染阴性组患者血清中 G-17、PG-Ⅰ和 PG-Ⅱ的含量。结果 HP 感染阳性组患者 G-17、PG-Ⅱ和 PG-Ⅰ/ PG-Ⅱ的阳性检出量明显高于阴性组，差异有统计学意义（P ﹤0.05），PG-Ⅰ在该两组之间的差异无统计学意义（P ﹥0.05）。结论 G-17和 PG-Ⅱ水平与 HP 感染有关联，可为 HP 感染或既往感染的诊断提供参考依据。
목적：검측유문라간균（HP）감염환자혈청중위비소-17（G-17）、위단백매원Ⅰ（PG-Ⅰ）화위단백매원Ⅱ（PG-Ⅱ）적함량，탐토기여 HP 감염발생적상관성。방법용 ELISA 법분별정량검측 HP 감염양성조화 HP 감염음성조환자혈청중 G-17、PG-Ⅰ화 PG-Ⅱ적함량。결과 HP 감염양성조환자 G-17、PG-Ⅱ화 PG-Ⅰ/ PG-Ⅱ적양성검출량명현고우음성조，차이유통계학의의（P ﹤0.05），PG-Ⅰ재해량조지간적차이무통계학의의（P ﹥0.05）。결론 G-17화 PG-Ⅱ수평여 HP 감염유관련，가위 HP 감염혹기왕감염적진단제공삼고의거。
Objective To detect the levels of gastrin-17(G-17),pepsinogen I(PG-Ⅰ)and pepsinogen Ⅱ(PG-Ⅱ)in serum of patients with Helicobacter pylori infection,and to evaluate the relationship between the occurrence of Helicobacter pylori infection and serum levels. Methods Serum was collected from cases of 41 male and 44 female with positive Helicobacter pylori,and 44 male and 41 female with negative Helicobacter pylori. Serum levels of G-17,PG-Ⅰ and PG-Ⅱ were quantitatively detected by ELISA. Results The serum lev-els of G-17,PG-Ⅱ and PG-Ⅰ/ PG-Ⅱ in Hp positive group were higher than those in Hp negative group,with significant differences in con-tent in serum of two groups(P ﹤ 0. 05);in each group of PG- I there was no significant statistically significant difference(P ﹥ 0. 05). Con-clusion Serum levels of G-17 and PG-Ⅱ levels are associated with Helicobacter pylori infection,which can be used as the relevant factors to provide reference basis for diagnosis of Helicobacter pylori infection or previous infection.