CAJ | 학술논문

目的：探讨盐酸美金刚对血管性痴呆（VaD）患者的临床疗效和对血清脑源性神经营养因子（BDNF）水平的影响。方法：采用随机双盲法将70例 VaD 患者分为治疗组和对照组，分别给予盐酸美金刚和安慰剂治疗6个月；分别于治疗前和治疗3、6个月给予简易精神状态检查（MMSE）、日常生活能力量表（ADL）评分和血清 BDNF 水平检测。结果：治疗后治疗组 MMSE 评分及血清 BDNF 水平明显提高，ADL 评分明显下降（P ﹤0.05或 P ﹤0.01）；对照组以上各指标治疗前后差异无统计学意义。结论：盐酸美金刚对 VaD 患者认知、行为能力有改善作用，可能与提高血清 BDNF 水平有关。
목적：탐토염산미금강대혈관성치태（VaD）환자적림상료효화대혈청뇌원성신경영양인자（BDNF）수평적영향。방법：채용수궤쌍맹법장70례 VaD 환자분위치료조화대조조，분별급여염산미금강화안위제치료6개월；분별우치료전화치료3、6개월급여간역정신상태검사（MMSE）、일상생활능역량표（ADL）평분화혈청 BDNF 수평검측。결과：치료후치료조 MMSE 평분급혈청 BDNF 수평명현제고，ADL 평분명현하강（P ﹤0.05혹 P ﹤0.01）；대조조이상각지표치료전후차이무통계학의의。결론：염산미금강대 VaD 환자인지、행위능력유개선작용，가능여제고혈청 BDNF 수평유관。
Objective:To explore the clincal curative effect of hydrochloride and the change of serum level of brain derived neurotrophic factor(BDNF)in patients with vascular dementia(VaD). Method:U-sing the randomized double blind method,the 70 VaD patients were divided into treatment group and control group;and treated by memantine hydrochloride and the placebo respectively for 6 months. All of the patients were assessed by mini mental dementia examination(MMSE)and activities of daily living(ADL);and their se-rum brain derived neurotrophic factor(BDNF)level was detected before treatment and 3,6 months after treat-ment. Results:Compared with before treatment,the score of MMSE and the level of serum BDNF in the treat-ment group were significantly higher,and the scores of ADL was significantly lower(P ﹤ 0. 05 or P ﹤ 0. 01);but there were no significant change in the control group. Conclusion:Memantine hydrochloride can improve the cognitive and behavioral ability in VaD patients. Its may be related to increased the level of serum BDNF.