国际妇产科学杂志
國際婦產科學雜誌
국제부산과학잡지
JOURNAL OF INTERNATIONAL OBSTETRICS AND GYNECOLOGY
2015年
4期
387-389
,共3页
流产,习惯性%甲状腺球蛋白%碘化物过氧化物酶%甲状腺自身抗体
流產,習慣性%甲狀腺毬蛋白%碘化物過氧化物酶%甲狀腺自身抗體
유산,습관성%갑상선구단백%전화물과양화물매%갑상선자신항체
Abortion,habitual%Thyroglobulin%Iodide peroxidase%Anti-thyroid antibody
目的:探讨甲状腺自身抗体(ATA)与复发性流产的相关性。方法:收集2013年8月—2014年4月于我院产科进行孕前检查,并符合入组条件的非妊娠期妇女,其中有复发性流产病史妇女92例,夫妻双方染色体检查未见异常,凝血功能相关检查无异常,为研究组;无复发性流产病史妇女226例,为对照组。检测2组对象甲状腺球蛋白抗体(TgAb)和甲状腺过氧化物酶抗体(TPOAb)的阳性率, TgAb(+)和(或)TPOAb(+)为ATA阳性。结果:①研究组中,年龄≥35岁及<35岁者的ATA阳性率分别为39.29%(11/28)和26.56%(17/64),差异无统计学意义(P>0.05);在对照组中则分别为25.00%(10/40)和18.28%(34/186),差异也无统计学意义(P>0.05),说明ATA在不同年龄阶段的状况相近。②研究组ATA阳性率为30.43%(28/92),高于对照组的19.47%(44/226),差异有统计学意义(P<0.05)。研究组TPOAb阳性率为30.43%(28/92),高于对照组的11.95%(27/226),差异有统计学意义(P<0.05)。研究组TgAb阳性率为7.61%(7/92),与对照组的7.52%(17/226)比较差异无统计学意义(P>0.05)。结论:ATA与复发性流产有关,尤其与TPOAb关系密切。
目的:探討甲狀腺自身抗體(ATA)與複髮性流產的相關性。方法:收集2013年8月—2014年4月于我院產科進行孕前檢查,併符閤入組條件的非妊娠期婦女,其中有複髮性流產病史婦女92例,伕妻雙方染色體檢查未見異常,凝血功能相關檢查無異常,為研究組;無複髮性流產病史婦女226例,為對照組。檢測2組對象甲狀腺毬蛋白抗體(TgAb)和甲狀腺過氧化物酶抗體(TPOAb)的暘性率, TgAb(+)和(或)TPOAb(+)為ATA暘性。結果:①研究組中,年齡≥35歲及<35歲者的ATA暘性率分彆為39.29%(11/28)和26.56%(17/64),差異無統計學意義(P>0.05);在對照組中則分彆為25.00%(10/40)和18.28%(34/186),差異也無統計學意義(P>0.05),說明ATA在不同年齡階段的狀況相近。②研究組ATA暘性率為30.43%(28/92),高于對照組的19.47%(44/226),差異有統計學意義(P<0.05)。研究組TPOAb暘性率為30.43%(28/92),高于對照組的11.95%(27/226),差異有統計學意義(P<0.05)。研究組TgAb暘性率為7.61%(7/92),與對照組的7.52%(17/226)比較差異無統計學意義(P>0.05)。結論:ATA與複髮性流產有關,尤其與TPOAb關繫密切。
목적:탐토갑상선자신항체(ATA)여복발성유산적상관성。방법:수집2013년8월—2014년4월우아원산과진행잉전검사,병부합입조조건적비임신기부녀,기중유복발성유산병사부녀92례,부처쌍방염색체검사미견이상,응혈공능상관검사무이상,위연구조;무복발성유산병사부녀226례,위대조조。검측2조대상갑상선구단백항체(TgAb)화갑상선과양화물매항체(TPOAb)적양성솔, TgAb(+)화(혹)TPOAb(+)위ATA양성。결과:①연구조중,년령≥35세급<35세자적ATA양성솔분별위39.29%(11/28)화26.56%(17/64),차이무통계학의의(P>0.05);재대조조중칙분별위25.00%(10/40)화18.28%(34/186),차이야무통계학의의(P>0.05),설명ATA재불동년령계단적상황상근。②연구조ATA양성솔위30.43%(28/92),고우대조조적19.47%(44/226),차이유통계학의의(P<0.05)。연구조TPOAb양성솔위30.43%(28/92),고우대조조적11.95%(27/226),차이유통계학의의(P<0.05)。연구조TgAb양성솔위7.61%(7/92),여대조조적7.52%(17/226)비교차이무통계학의의(P>0.05)。결론:ATA여복발성유산유관,우기여TPOAb관계밀절。
Objective:To investigate the relationship between antithyroid antibodies (ATA) and recurrent spontaneous abortion (RSA). Methods:Collected the women undergoing the examinations before pregnancy in out-patient department from August 2013 to March 2014,and according with the criterion had made for the study. 92 women had RSA history were in the study group,and their chromosome and coagulation function tests were normal. 226 women without RSA history were in the control group. TgAb(+) and/or TPOAb(+) suggested ATA(+). Results:①In study group,the position rate of ATA in 35 years old and above women and younger than 35 years old was 39.29%(11/28) and 26.56%(17/64) respectively. There was no statistical significance (P>0.05). And in control group was 25.00%(10/40) and 18.28%(34/186) respectively, no statistical significance (P>0.05). So we thought ATA positive rate in different age stage was similar.②ATA positive rate was 30.43%(28/92) in study group,higher than the control′s 19.47%(44/226),the difference had statistical significance (P<0.05). TPOAb positive rate in study and control group was 30.43%(28/92) and 11.95%(27/226),the difference had statistical significance (P<0.05). TgAb positive rate was 7.61%(7/92)in the study group,although it was higher than the control 7.52%(17/226),but no statistical significance(P>0.05). Conclusions:ATA was related with RSA significantly, especially TPOAb.