CAJ | 학술논문

目的：观察ω-3多不饱和脂肪酸（ω-3 PUFA）对严重烧伤患者心肌功能的影响。方法将2013年1月至2014年12月安徽医科大学第一附属医院烧伤科收治且符合纳入标准的24例危重患者随机分为两组。对照组12例为常规治疗的基础上使用20%中长链脂肪乳治疗，治疗组12例为常规治疗基础上使用ω-3 PUFA，均持续使用7 d。留取治疗前及治疗后1、4、7 d 静脉血，并检测 TNF-α、IL-6、cTnI、NF-κBp65值。对统计资料进行析因方差分析。结果治疗后，治疗组与对照组血标本中 TNF-α、IL-6、cTnI、NF-κBp65值水平均较治疗前均降低，且治疗后，治疗组 TNF-α、IL-6、cTnI、NF-κBp65值水平均明显低于对照组，差异有统计学意义（P ﹤0.01）。结论ω-3 PUFA 可改善严重烧伤患者心肌功能。
목적：관찰ω-3다불포화지방산（ω-3 PUFA）대엄중소상환자심기공능적영향。방법장2013년1월지2014년12월안휘의과대학제일부속의원소상과수치차부합납입표준적24례위중환자수궤분위량조。대조조12례위상규치료적기출상사용20%중장련지방유치료，치료조12례위상규치료기출상사용ω-3 PUFA，균지속사용7 d。류취치료전급치료후1、4、7 d 정맥혈，병검측 TNF-α、IL-6、cTnI、NF-κBp65치。대통계자료진행석인방차분석。결과치료후，치료조여대조조혈표본중 TNF-α、IL-6、cTnI、NF-κBp65치수평균교치료전균강저，차치료후，치료조 TNF-α、IL-6、cTnI、NF-κBp65치수평균명현저우대조조，차이유통계학의의（P ﹤0.01）。결론ω-3 PUFA 가개선엄중소상환자심기공능。
Objective To investigate the effection of ω-3 polyunsaturated fatty acids(PUFAs)on myocardial function in seriously burned patients. Methods 24 cases of seriously burned patients satisfying the inclusion criteria,ever treated in our hospital from Jan 2013 to Dec 2014,were randomly divided into two groups. Amedium- and long-chain fat emulsion injection(20% )with conventional therapy were used to treat patients in the control group,and the treatment group were given ω-3 PUFA on the basis of conventional treatment. With contin-uously treatment of 7 days,serum levels of TNF-α,IL-6,cTnI,NF-κBp65 of patients in both groups were measured before treatment and at 1d,4d,7d after treatment. Statistical data were analyzed by factorial ANOVA. Results After treatment,levels of TNF-α,IL-6,cTnI,NF-κBp65 of all 24 patients declined,and levels in the treatment group were lower than that in the control group,with statistically significant difference(P ﹤ 0. 01). Conclusion Treatment with ω-3 PUFA may improve myocardial function in patients with severe burns.