CAJ | 학술논문

子宫内膜异位症（EMs）因其具有侵袭、易复发等特点被称为类肿瘤性疾病。近年随着EMs病因学研究不断深入，子宫内膜中存在干细胞且这些干细胞参与子宫内膜的周期性活动的观点得以提出并陆续被验证，进而EMs干细胞学说逐渐得到认可。在干细胞研究中随着分子生物学方法的应用，证明了越来越多的基因和信号通路参与了干细胞的周期性调节，其中Wnt/β-catenin信号通路是干细胞的重要通路之一。 Wnt/β-catenin信号通路以其高度保守、结构复杂性而在多种肿瘤的发生发展中通过影响干细胞增殖周期发挥作用，同时Wnt/β-catenin信号通路参与调节子宫内膜干细胞，这将为EMs的发生、发展及治疗提供新的思路。
자궁내막이위증（EMs）인기구유침습、역복발등특점피칭위류종류성질병。근년수착EMs병인학연구불단심입，자궁내막중존재간세포차저사간세포삼여자궁내막적주기성활동적관점득이제출병륙속피험증，진이EMs간세포학설축점득도인가。재간세포연구중수착분자생물학방법적응용，증명료월래월다적기인화신호통로삼여료간세포적주기성조절，기중Wnt/β-catenin신호통로시간세포적중요통로지일。 Wnt/β-catenin신호통로이기고도보수、결구복잡성이재다충종류적발생발전중통과영향간세포증식주기발휘작용，동시Wnt/β-catenin신호통로삼여조절자궁내막간세포，저장위EMs적발생、발전급치료제공신적사로。
Endometriosis (EMs) is characterized as class neoplastic disease because of its invasiveness,easy to relapse and other neoplastic diseases character. In recent years ,with the development of EMs etiology study ,the existence of stem cells in the endometrium and these stem cells are involved in the endometrial cyclical activities have been proposed and validated ,and then EMs stem cell theory is gradually being recognized. In the research of stem cell as the application of molecular biology method,a growing number of genes and signaling pathways involved in stem cells proved to be take part in stem cell′s cyclical activity,of which Wnt/β-catenin signaling pathway is one of the most important research pathways of stem cells. Wnt/β-catenin signaling pathway is highly conserved in its structural complexity in the development of a variety of tumors by stem cell proliferation cycle play a role,meanwhile Wnt/β-catenin signaling pathway involved in endometrial stem cell regulation,which would provide new ideas for the occurrence, development and treatment of endometriosis.