CAJ | 학술논문

目的：探讨宫颈癌患者外周血中白细胞介素（IL ）‐6、IL‐8、IL‐17的浓度以及临床意义。方法选取该院2012年1月至2013年12月收治的宫颈癌患者87例作为宫颈癌组，另选同期病理检查宫颈组织正常的患者50例作为对照组，检测2组患者外周血中IL‐6、IL‐8、IL‐17的浓度。结果宫颈癌组IL‐6、IL‐8、IL‐17浓度均明显高于对照组，差异有统计学意义（ P＜0．05）；IL‐6、IL‐8、IL‐17浓度Ⅳ期明显高于Ⅲ期，Ⅲ期明显高于Ⅱ期，Ⅱ期明显高于Ⅰ期，差异有统计学意义（ P＜0．05）；IL‐6、IL‐8、IL‐17浓度中低分化明显高于中分化，中分化明显高于高分化，差异有统计学意义（ P＜0．05）。结论 IL‐6、IL‐8、IL‐17与宫颈癌的发生、进展、分化密切相关，对IL‐6、IL‐8、IL‐17的监测有助于疾病的诊断，对疾病的进展判断有一定价值。
목적：탐토궁경암환자외주혈중백세포개소（IL ）‐6、IL‐8、IL‐17적농도이급림상의의。방법선취해원2012년1월지2013년12월수치적궁경암환자87례작위궁경암조，령선동기병리검사궁경조직정상적환자50례작위대조조，검측2조환자외주혈중IL‐6、IL‐8、IL‐17적농도。결과궁경암조IL‐6、IL‐8、IL‐17농도균명현고우대조조，차이유통계학의의（ P＜0．05）；IL‐6、IL‐8、IL‐17농도Ⅳ기명현고우Ⅲ기，Ⅲ기명현고우Ⅱ기，Ⅱ기명현고우Ⅰ기，차이유통계학의의（ P＜0．05）；IL‐6、IL‐8、IL‐17농도중저분화명현고우중분화，중분화명현고우고분화，차이유통계학의의（ P＜0．05）。결론 IL‐6、IL‐8、IL‐17여궁경암적발생、진전、분화밀절상관，대IL‐6、IL‐8、IL‐17적감측유조우질병적진단，대질병적진전판단유일정개치。
Objective To investigate the peripheral blood IL‐6 ,IL‐8 and IL‐17 contents and clinical signifi‐cance in the patients with cervical cancer .Methods 87 cases of cervical cancer in our hospital from January 2012 to December 2013 were selected as the cervical cancer group and contemporaneous 50 patients with normal cervical de‐termined by pathology were selected as the control group .The peripheral blood IL‐6 ,IL‐8 and IL‐17 content were de‐tected in the two groups .Results The IL‐6 ,IL‐8 and IL‐17 levels in the cervical cancer group were significantly higher than those in the control group with statistical difference(P< 0 .05);the IL‐6 ,IL‐8 and IL‐17 levels in the stage Ⅳ were significantly higher than those in the stage Ⅲ ,moreover the stage Ⅲ was significantly higher than the stage Ⅱ and the stage Ⅱ was significantly higher than the stage Ⅰ ,the differences were statistically significance(P<0 .05);the IL‐6 ,IL‐8 and IL‐17 levels in the middle and low differentiation were significantly higher than those in the high differentiation ,the differences were statistically significant(P< 0 .05) .Conclusion IL‐6 ,IL‐8 and IL‐17 are closely correlated with the occurrence ,progression and differentiation of cervical cancer ,monitoring IL‐6 ,IL‐8 and IL‐17 is conducive to the diagnosis of cervical cancer and has certain value for judgment of the disease progression .