CAJ | 학술논문

目的：探讨血液灌流（HP）联合连续性血液滤过（CVVH）治疗难治性肾病综合征（RNS）的疗效观察。方法选取该院肾内科收治的RNS患者60例，按照治疗方法的不同，分为对照组和观察组各30例。对照组给予常规药物治疗和对症治疗，观察组在对照组的基础上，给予 HP联合CVVH 治疗，比较2组治疗效果和结果。结果观察组显效率和总有效率高于对照组，无效率低于对照组，差异有统计学意义（P＜0．05）。此外，2组患者各指标均有所优化，且观察组治疗后各指标均优于对照组，同时，观察组患者的存活率高于对照组，差异有统计学意义（P＜0．05）。结论 HP联合CVVH治疗RNS ，可提高治疗有效率，改善患者体内炎性反应相关因子水平、血脂水平等指标，提高患者生存率，为 HP联合CVVH治疗RNS的临床应用提供参考。
목적：탐토혈액관류（HP）연합련속성혈액려과（CVVH）치료난치성신병종합정（RNS）적료효관찰。방법선취해원신내과수치적RNS환자60례，안조치료방법적불동，분위대조조화관찰조각30례。대조조급여상규약물치료화대증치료，관찰조재대조조적기출상，급여 HP연합CVVH 치료，비교2조치료효과화결과。결과관찰조현효솔화총유효솔고우대조조，무효솔저우대조조，차이유통계학의의（P＜0．05）。차외，2조환자각지표균유소우화，차관찰조치료후각지표균우우대조조，동시，관찰조환자적존활솔고우대조조，차이유통계학의의（P＜0．05）。결론 HP연합CVVH치료RNS ，가제고치료유효솔，개선환자체내염성반응상관인자수평、혈지수평등지표，제고환자생존솔，위 HP연합CVVH치료RNS적림상응용제공삼고。
Objective To observe the effect of hemoperfusion (HP) combined with continuous veno‐venous hemofiltration (CVVH) in treating refractory nephropathy syndrome (RNS) .Methods 60 cases of RNS in our hos‐pital were chosen and divided into two groups .The control group was given the routine medication treatment and symptomatic treatment ,while on this basis the observation group was given HP combined with CVVH .The clinical effects and outcomes were performed the comparative analysis .Results The significant efficiency and total efficiency of the observation group were higher than those of the control ,the differences were statistically significant ( P<0 .05) .Besides ,the detected indexes in the two groups were improved ,but the various indexes after treatment in the observation group were superior to those in the control group ,and the survival rate was higher than that in the con‐trol group ,the differences were statistically significant(P<0 .05) .Conclusion This research confirms that HP com‐bined with CVVH in the treatment of RNS can increase the clinical effective rate ,improves the inflammatory reaction related factors levels and blood lipid levels and increases the survival rate ,which provides reference for the application of HP combined with CVVH in treating RNS .