CAJ | 학술논문

目的：观察急性冠状动脉综合征（ ACS）患者血浆脑肠肽、肥胖抑制素水平变化，并探讨其临床意义。方法研究对象为108例ACS患者（ A组）、30例健康体检者（ B组），采用放射免疫法检测两组血浆脑肠肽、肥胖抑制素的水平，并分析其与ACS危险因素的相关性。结果 A组BMI、LDL、血压、颈动脉内中膜厚度（ IMT）、颈动脉斑块所占比例明显高于B组（P均＜0．05），血糖水平升高但差异无统计学意义。与B组比较，A组血浆脑肠肽水平降低、肥胖抑制素水平升高（P均＜0．05），血浆脑肠肽／肥胖抑制素比值降低（P＜0．05）。相关性分析显示，A组血浆脑肠肽水平与BMI、IMT、LDL呈负相关（r分别为－0．17、－0．31、－0．22，P均＜0．05）；血浆肥胖抑制素水平与IMT、LDL呈正相关（r分别为0．29、0．24，P均＜0．05）。结论 ACS患者血浆脑肠肽水平降低、肥胖抑制素水平升高，二者可能参与了ACS的发生、发展。
목적：관찰급성관상동맥종합정（ ACS）환자혈장뇌장태、비반억제소수평변화，병탐토기림상의의。방법연구대상위108례ACS환자（ A조）、30례건강체검자（ B조），채용방사면역법검측량조혈장뇌장태、비반억제소적수평，병분석기여ACS위험인소적상관성。결과 A조BMI、LDL、혈압、경동맥내중막후도（ IMT）、경동맥반괴소점비례명현고우B조（P균＜0．05），혈당수평승고단차이무통계학의의。여B조비교，A조혈장뇌장태수평강저、비반억제소수평승고（P균＜0．05），혈장뇌장태／비반억제소비치강저（P＜0．05）。상관성분석현시，A조혈장뇌장태수평여BMI、IMT、LDL정부상관（r분별위－0．17、－0．31、－0．22，P균＜0．05）；혈장비반억제소수평여IMT、LDL정정상관（r분별위0．29、0．24，P균＜0．05）。결론 ACS환자혈장뇌장태수평강저、비반억제소수평승고，이자가능삼여료ACS적발생、발전。
Objective To investigate the mechanism and significance of ghrelin and obestatin in the occurrence and development of acute coronary syndrome (ACS).Methods A total of 108 ACS patients (group A) and 30 healthy peo-ple(group B) were selected.The levels of ghrelin and obestatin in plasma were detected by radioimmunoassay , and the correlations of ghrelin and obestatin levels with the risk factors of ACS were analyzed .Results Compared with group B , the body mass index(BMI),low density lipoprotein (LDL), blood pressure, intima-media thickness(IMT)and the propor-tion of carotid plaques were significantly higher in the group A (P<0.05), the blood glucose levels increased , but it was not statistically significant .The ghrelin level was significantly lower and the obestatin level was significantly higher in the group A as compared with those of group B (all P<0.05).The G/O ratio of the group A was significantly lower than that of group B (P<0.05).Correlation analysis showed that the level of ghrelin in plasma was negatively correlated with BMI , LDL and IMT (r=-0.17,-0.31 and -0.22;all P<0.05);the level of obestatin in plasma was positively correlated with LDL and IMT(r=0.29, 0.24;all P<0.05).Conclusions The expression of plasma ghrelin and obestatin was ab-normal in ACS patients , which may participate in the occurrence and development of atherosclerosis .