CAJ | 학술논문

目的：探讨血清癌胚抗原（CEA ）、糖链抗原199（CA199）、糖链抗原125（CA125）和糖链抗原724（CA724）联合检测在结直肠癌辅助诊断和临床参数的相关性。方法回顾性分析结直肠癌组164例、结直肠良性病变组56例、健康对照组49例的血清CEA、CA199、CA125和CA724浓度，统计分析4种肿瘤标志物在健康对照组、结直肠良性病变组和结直肠癌组中的阳性率以及其浓度与结直肠癌临床病理资料的相关性。结果结直肠癌患者血清CEA、CA199、CA125和CA724阳性率明显高于结直肠良性病变患者及健康者，差异有统计学意义（ P＜0．05），联合检测血清CEA、CA199、CA125和CA724可明显提高结直肠癌诊断的敏感度；血清CEA与结直肠癌局部浸润程度、淋巴结转移、远处转移和临床分期相关；血清CA199、CA125和CA724浓度与远处转移相关；血清CA724在结直肠黏液腺癌中明显高于其他病理类型；血清CA125和CA724与大肠癌解剖部位有关；血清CEA和CA199与癌组织Ki‐67表达水平呈负相关。结论血清CEA、CA199、CA125和CA724对结直肠癌临床辅助诊断有一定价值，4者联合检测可提高结直肠癌的检出率；血清CEA、CA199、CA125和CA724与结直肠癌临床病理参数有关，可作为结直肠癌预后和预测标志物。
목적：탐토혈청암배항원（CEA ）、당련항원199（CA199）、당련항원125（CA125）화당련항원724（CA724）연합검측재결직장암보조진단화림상삼수적상관성。방법회고성분석결직장암조164례、결직장량성병변조56례、건강대조조49례적혈청CEA、CA199、CA125화CA724농도，통계분석4충종류표지물재건강대조조、결직장량성병변조화결직장암조중적양성솔이급기농도여결직장암림상병리자료적상관성。결과결직장암환자혈청CEA、CA199、CA125화CA724양성솔명현고우결직장량성병변환자급건강자，차이유통계학의의（ P＜0．05），연합검측혈청CEA、CA199、CA125화CA724가명현제고결직장암진단적민감도；혈청CEA여결직장암국부침윤정도、림파결전이、원처전이화림상분기상관；혈청CA199、CA125화CA724농도여원처전이상관；혈청CA724재결직장점액선암중명현고우기타병리류형；혈청CA125화CA724여대장암해부부위유관；혈청CEA화CA199여암조직Ki‐67표체수평정부상관。결론혈청CEA、CA199、CA125화CA724대결직장암림상보조진단유일정개치，4자연합검측가제고결직장암적검출솔；혈청CEA、CA199、CA125화CA724여결직장암림상병리삼수유관，가작위결직장암예후화예측표지물。
Objective To explore the correlation between the combined detection of CEA ,CA199 ,CA125 and CA724 with the assisted diagnosis of colorectal cancer and clinical parameters .Methods The serum levels of CEA , CA199 ,CA125 and CA724 in 164 patients with colorectal cancer ,56 patients with benign colorectal diseases and 49 normal control subjects were performed the retrospective analysis ,and furthermore the positive detection rates of these 4 kinds of tumor marker in the normal control ,benign colorectal diseases and colorectal cancer and the correla‐tion between the levels of above markers and clinical clinicopathological data of colorectal cancer were statistically an‐alyzed .Results The positive rates of serum CEA ,CA199 ,CA125 and CA724 in the patients with colorectal cancer were significantly higher than those with benign lung diseases and normal controls ,the differences were statistically significant (P<0 .05);the combined detection of serum CEA ,CA199 ,CA125 and CA724 could obviously increase the sensitivity for diagnosing colorectal cancer ;the serum CEA level was related to the tumor local invasion degree ,lymph node metastasis ,distant metastasis and clinical staging ;the serum CA199 ,CA125 and CA724 levels were related to the distant metastasis of colorectal carcinoma;the serum CA724 level in mucinous adenocarcinoma was higher than that in the other pathological types ;the serum CA125 and CA724 levels were related to tumor anatomic location;the serum CEA and CA199 levels were negatively correlated to the Ki‐67 expression level of colorectal carcinoma tissue . Conclusion The serum levels of CEA ,CA199 ,CA125 and CA724 has certain value for the clinical assisted diagnosis of colorectal cancer ,their combined detection could improve the detection rate of colorectal cancer .The serum levels of CEA ,CA199 ,CA125 and CA724 are associated with the clinicopathological parameters and can serve as the mark‐ers of prognosis and prediction of colorectal cancer .