CAJ | 학술논문

目的：探讨尿液对羟基苯丙氨酸检测在恶性肿瘤预测中的临床应用价值。方法采用比色法对重庆市肿瘤研究所395例尿液样本（其中90例健康者、92例良性肿瘤、213例病理确诊的恶性肿瘤）对羟基苯丙氨酸进行检测分析。结果健康对照组、良性肿瘤组、恶性肿瘤组的阳性检出率分别为8．89％、14．13％、68．54％；与健康对照组比较，良性肿瘤组的阳性率差异无统计学意义（P＞0．05），恶性肿瘤组的阳性率明显升高，差异有统计学意义（P＜0．05）；与良性肿瘤组比较，恶性肿瘤组的阳性率明显升高，差异有统计学意义（P＜0．05）；恶性肿瘤组中的消化道恶性肿瘤、鼻咽癌、淋巴瘤、乳腺癌、妇科恶性肿瘤、肺癌及其他恶性肿瘤的阳性检出率分别是78．82％、72．22％、71．42％、65．38％、62．50％、60．00％和72．22％，不同病种间的阳性率差异无统计学意义（ P＞0．05）；尿液对羟基苯丙氨酸对恶性肿瘤的检测灵敏度68．54％，特异性88．46％，准确度77．72％，阳性预测值87．00％，阴性预测值71．00％。结论尿液对羟基苯丙氨酸作为一种新的肿瘤标志物，适用于恶性肿瘤的广谱筛查；对良、恶性肿瘤的鉴别诊断具有重要的临床意义。
목적：탐토뇨액대간기분병안산검측재악성종류예측중적림상응용개치。방법채용비색법대중경시종류연구소395례뇨액양본（기중90례건강자、92례량성종류、213례병리학진적악성종류）대간기분병안산진행검측분석。결과건강대조조、량성종류조、악성종류조적양성검출솔분별위8．89％、14．13％、68．54％；여건강대조조비교，량성종류조적양성솔차이무통계학의의（P＞0．05），악성종류조적양성솔명현승고，차이유통계학의의（P＜0．05）；여량성종류조비교，악성종류조적양성솔명현승고，차이유통계학의의（P＜0．05）；악성종류조중적소화도악성종류、비인암、림파류、유선암、부과악성종류、폐암급기타악성종류적양성검출솔분별시78．82％、72．22％、71．42％、65．38％、62．50％、60．00％화72．22％，불동병충간적양성솔차이무통계학의의（ P＞0．05）；뇨액대간기분병안산대악성종류적검측령민도68．54％，특이성88．46％，준학도77．72％，양성예측치87．00％，음성예측치71．00％。결론뇨액대간기분병안산작위일충신적종류표지물，괄용우악성종류적엄보사사；대량、악성종류적감별진단구유중요적림상의의。
Objective To discuss the clinical application value of urine hydroxyl phenylalanine in predicting malignant tumor .Methods Hydroxyl phenylalanine in 395 urine samples (90 healthy subjects ,92 patients with be‐nign tumor ,213 patients with malignant tumor) was detected by the hydroxy phenylalanine kits .Results The posi‐tive detection rate was 8 .89% in the normal group ,14 .13% in the benign tumor group and 68 .54% in the malignant tumor group .Compared with the normal group ,the positive detection rate in the benign tumor group had no obviously difference (P>0 .05);Compared with the benign tumor group ,the positive detection rate in the malignant tumor group was obviously increased with statistical difference(P<0 .05);the positive detection rate was 78 .82% in diges‐tive tract malignant tumor ,72 .22% in nasopharyngeal carcinoma ,71 .42% in lymphoma ,65 .38% in breast cancer , 62 .50% in gynecologic malignant tumors ,60 .00% in lung cancer and 72 .22% in other malignant tumors .The posi‐tive detection rates had no statistical differences among different types of tumor (P>0 .05) .The sensitivity ,specifici‐ty ,accuracy ,positive predictive value and negative predictive value of urine hydroxyl phenylalanine for predicting ma‐lignant tumor were 68 .54% ,88 .46% ,77 .72% ,87 .00% and 71 .00% ,respectively .Conclusion Urine hydroxy phen‐ylalanine as a new tumor marker is suitable for the broad spectrum screening of malignant tumor ,which has an im‐portant significance for the differentiation diagnosis of benign and malignant tumors .