CAJ | 학술논문

目的：观察耳前耳后注射地塞米松、庆大霉素治疗梅尼埃病（M D ）的临床疗效。方法选取2011年6月至2014年1月该院就诊的M D患者96例，根据随机原则将患者分为3组：地塞米松组（DX组）、庆大霉素组（GM组），生理盐水组（NS组）。按试验设计采用地塞米松、庆大霉素分别耳前、耳后各注射0．5 mL ，每周1次，共给药4次，按时观察听功能，前庭功能变化情况以及活动能力的控制情况。结果治疗18个月后，DX组眩晕控制率72．73％，GM组眩晕控制率75．86％，NS组眩晕控制率12．12％，DX组与NS组、GM 组与NS组眩晕控制率比较，差异有统计学意义（P＜0．01），DX组、GM 组对眩晕控制均有效；DX组听力改善率39．39％，GM 组听力改善率6．89％，NS组听力改善率9．09％，DX组与GM、NS组比较，听力改善差异有统计学意义（P＜0．01），DX组对听力改善有效；DX组活动能力改善率75．76％，GM组活动能力改善率72．41％，NS组活动能力改善率15．15％，DX组与NS组、GM组与NS组活动能力控制率比较差异有统计学意义（P＜0．01），DX组、GM 组对活动能力控制均有效。结论经耳前耳后分别注射地塞米松、庆大霉素是一条治疗MD简单安全有效的新途径。
목적：관찰이전이후주사지새미송、경대매소치료매니애병（M D ）적림상료효。방법선취2011년6월지2014년1월해원취진적M D환자96례，근거수궤원칙장환자분위3조：지새미송조（DX조）、경대매소조（GM조），생리염수조（NS조）。안시험설계채용지새미송、경대매소분별이전、이후각주사0．5 mL ，매주1차，공급약4차，안시관찰은공능，전정공능변화정황이급활동능력적공제정황。결과치료18개월후，DX조현훈공제솔72．73％，GM조현훈공제솔75．86％，NS조현훈공제솔12．12％，DX조여NS조、GM 조여NS조현훈공제솔비교，차이유통계학의의（P＜0．01），DX조、GM 조대현훈공제균유효；DX조은력개선솔39．39％，GM 조은력개선솔6．89％，NS조은력개선솔9．09％，DX조여GM、NS조비교，은력개선차이유통계학의의（P＜0．01），DX조대은력개선유효；DX조활동능력개선솔75．76％，GM조활동능력개선솔72．41％，NS조활동능력개선솔15．15％，DX조여NS조、GM조여NS조활동능력공제솔비교차이유통계학의의（P＜0．01），DX조、GM 조대활동능력공제균유효。결론경이전이후분별주사지새미송、경대매소시일조치료MD간단안전유효적신도경。
Objective To observe the clinical curative effect of prootic and opisthotic injection of dexametha‐sone and gentamicin for treating Meniere disease(MD) .Methods 96 patients with MD in our hospital from June 2011 to January 2014 were selected and randomly divided into the dexamethasone group (DX group) ,gentamycin group(GM group) and the normal saline group(NS group) .According to the experimental design ,gentamycin 0 .5 mL and dexamethasone 0 .5 mL were given by prootic and opisthotic injection ,once per week ,totally 4 times .The hearing function ,vestibular function and control situation of mobility capacity were regularly observed .Results After 18‐month treatment ,the vertigo control rate was 72 .73% in the DX group ,75 .86% in the GM group and 12 .12% in the NS group ,the differences between the DX group and the NS group and between the GM group and the NS group had statistical significance (P<0 .01) ,the vertigo control in the DX group and the GM group were proved to be ef‐fective;the improvement rate of hearing function was 39 .39% in the DX group ,6 .89% in the GM group and 9 .09%in the NS group ,the difference between the DX group and the GM group had statistical significance (P<0 .01);the improvement rate of mobility capacity was 75 .76% in the DX group ,72 .41% in the GM group and 15 .15% in the NS group ,the differences between the DX group and the NS group and between the GM group and the NS group had statistical significance (P< 0 .01) ,the mobility capacity was effectively controlled in the DX group and the GM group .Conclusion Prootic and opisthotic injection of dexamethasone and gentamicin for treating MD is a simple ,safe and effective new path for treating MD .