大理学院学报
大理學院學報
대이학원학보
JOURNAL OF DALI COLLEGE
2015年
8期
49-52
,共4页
Survivin%OPN%免疫组化%慢性宫颈炎%宫颈上皮内瘤%宫颈鳞癌
Survivin%OPN%免疫組化%慢性宮頸炎%宮頸上皮內瘤%宮頸鱗癌
Survivin%OPN%면역조화%만성궁경염%궁경상피내류%궁경린암
Survivin%OPN%immunohistochemical%chronic cervicitis%CIN%cervical squamous carcinomas
目的:探讨Survivin、OPN在慢性宫颈炎、宫颈上皮内瘤(CIN)、宫颈鳞癌组织中的表达情况。方法:采用免疫组织化学SP法检测Survivin、OPN在10例慢性宫颈炎、20例宫颈上皮内瘤变Ⅲ期(CINⅢ)和50例宫颈鳞癌组织中的表达情况。结果:Survivin和OPN在慢性宫颈炎、CINⅢ、宫颈鳞癌中的表达阳性率均随病变严重程度逐级增强,3组比较差异均有统计学意义(P<0.05)。Survivin的表达阳性率与宫颈鳞癌的临床分期、病理分级有关(P<0.05),与年龄、有无淋巴结转移无关(P>0.05);Survivin的表达阳性率与宫颈鳞癌的临床分期、有无淋巴结转移有关(P<0.05),与年龄、病理分级无关(P>0.05)。结论:Sur?vivin+OPN的联合检测有可能作为宫颈鳞癌的早期诊断、病情监测和预后判断的指标。
目的:探討Survivin、OPN在慢性宮頸炎、宮頸上皮內瘤(CIN)、宮頸鱗癌組織中的錶達情況。方法:採用免疫組織化學SP法檢測Survivin、OPN在10例慢性宮頸炎、20例宮頸上皮內瘤變Ⅲ期(CINⅢ)和50例宮頸鱗癌組織中的錶達情況。結果:Survivin和OPN在慢性宮頸炎、CINⅢ、宮頸鱗癌中的錶達暘性率均隨病變嚴重程度逐級增彊,3組比較差異均有統計學意義(P<0.05)。Survivin的錶達暘性率與宮頸鱗癌的臨床分期、病理分級有關(P<0.05),與年齡、有無淋巴結轉移無關(P>0.05);Survivin的錶達暘性率與宮頸鱗癌的臨床分期、有無淋巴結轉移有關(P<0.05),與年齡、病理分級無關(P>0.05)。結論:Sur?vivin+OPN的聯閤檢測有可能作為宮頸鱗癌的早期診斷、病情鑑測和預後判斷的指標。
목적:탐토Survivin、OPN재만성궁경염、궁경상피내류(CIN)、궁경린암조직중적표체정황。방법:채용면역조직화학SP법검측Survivin、OPN재10례만성궁경염、20례궁경상피내류변Ⅲ기(CINⅢ)화50례궁경린암조직중적표체정황。결과:Survivin화OPN재만성궁경염、CINⅢ、궁경린암중적표체양성솔균수병변엄중정도축급증강,3조비교차이균유통계학의의(P<0.05)。Survivin적표체양성솔여궁경린암적림상분기、병리분급유관(P<0.05),여년령、유무림파결전이무관(P>0.05);Survivin적표체양성솔여궁경린암적림상분기、유무림파결전이유관(P<0.05),여년령、병리분급무관(P>0.05)。결론:Sur?vivin+OPN적연합검측유가능작위궁경린암적조기진단、병정감측화예후판단적지표。
Objective: To discuss the expressions of Survivin and OPN in the tissues of chronic cervitis, cervical intraepithelial neoplasia(CIN)and cervical squamous carcinoma. Methods:Immunohistochemical SP method was applied to detect the expressions of Survivin and OPN in 10 cases of chronic cervicitis, 20 cases of CIN and 50 cases of cervical cancer. Results: The expression positive rate of Survivin and OPN in chronic cervicitis、CINⅢ、cervical squamous carcinomas increased with the lesion severity level enhancement,three groups of comparative differences are statistically significant(P<0.05). The expression positive rate of Survivin in cervical squamous carcinomas was associated with clinical stages and pathologic stage(P<0.05), but has nothing to do with age and lymph nodes metastasis(P>0.05). The expression positive rate of OPN in cervical squamous carcinomas was associated with clinical stages and lymph node metastasis(P<0.05), but has nothing to do with age and pathologic stage(P>0.05). Conclusion:The joint detection of Survivin and OPN may serve as the index for early diagnosis, condition monitoring and prognosis judgment of cervical squamous carcinomas.