CAJ | 학술논문

目的：提高对肠道套细胞淋巴瘤的认识。方法：回顾性分析广州中山大学第一附属医院内镜中心2008年5月至2012年6月经肠镜及免疫组化检查确诊为肠道套细胞淋巴瘤6例患者的临床资料，尤其是病理及肠镜表现。结果：肠道套细胞淋巴瘤主要好发于老年男性，肠镜下肠道多呈多发性淋巴瘤样息肉改变。免疫组化显示几乎所有病例均表达T细胞相关抗原CD5，过度表达细胞周期素D1（CyclinD1），部分可表达CD43而CD23、CD10（-）。结论：肠道套细胞淋巴瘤是一种难治性淋巴瘤，预后较差，肠镜下获取优良的病理标本并进行免疫分型是诊断的最重要手段。
목적：제고대장도투세포림파류적인식。방법：회고성분석엄주중산대학제일부속의원내경중심2008년5월지2012년6월경장경급면역조화검사학진위장도투세포림파류6례환자적림상자료，우기시병리급장경표현。결과：장도투세포림파류주요호발우노년남성，장경하장도다정다발성림파류양식육개변。면역조화현시궤호소유병례균표체T세포상관항원CD5，과도표체세포주기소D1（CyclinD1），부분가표체CD43이CD23、CD10（-）。결론：장도투세포림파류시일충난치성림파류，예후교차，장경하획취우량적병리표본병진행면역분형시진단적최중요수단。
Objective: To improve the awareness of intestinal mantle cell lymphoma. Methods: Six clinical cases which were identified as intestinal mantle cell lymphoma through colonoscopy and immunohistochemistry by the First Affiliated Hospital of Sun Yat-sen University from May 2008 to June 2012 were retrospectively analyzed. Results: It is clear that a significant percentage of intestinal mantle cell lymphoma occurs in old aged male. Multiple lymphomatous polyposis has been found in intestine under colonoscopy. Furthermore, immunohistochemistry presents that most all cases express T-cell associated antigen CD 5, and over express cycling D1. At the same time, some cases also express CD43, while others show the negative CD23 and CD10. Conclusion:Intestinal mantle cell lymphoma is a refractory lymphoma with limited curative effect. Biopsy specimen by colonoscopy and process immunophenotype is an important diagnosis method.