CAJ | 학술논문

目的：探讨云南滇西高海拔地区健康人群慢性高原病（CMS）的发病风险。方法：从骨密度、血细胞分析、血液流变学、血液生化和免疫功能等5个方面对不同海拔高度地区健康人群慢性高原病的发病风险进行分析。结果：随着海拔升高，人群骨密度逐渐增加；血液RBC、Hb等逐渐增高，血液黏稠度增加，差异有统计学意义（P＜0.05）；肝功能除TP、Alb及Glu外其余指标均随海拔升高而升高，肾功能和心肌酶谱各指标亦随海拔升高而升高；大理组和维西组TC、TG、LDL-C、APoB、IgG、IgM、IgA、C3、C4水平显著低于香格里拉组（P＜0.05），低于德钦组（P＜0.05）；随海拔升高，CD3+、CD8+逐渐增高且相邻两组间差异有统计学意义（P＜0.05）。结论：健康人群各项功能指标随海拔升高有不同的改变，患慢性高原病的危险性逐渐增加。
목적：탐토운남전서고해발지구건강인군만성고원병（CMS）적발병풍험。방법：종골밀도、혈세포분석、혈액류변학、혈액생화화면역공능등5개방면대불동해발고도지구건강인군만성고원병적발병풍험진행분석。결과：수착해발승고，인군골밀도축점증가；혈액RBC、Hb등축점증고，혈액점주도증가，차이유통계학의의（P＜0.05）；간공능제TP、Alb급Glu외기여지표균수해발승고이승고，신공능화심기매보각지표역수해발승고이승고；대리조화유서조TC、TG、LDL-C、APoB、IgG、IgM、IgA、C3、C4수평현저저우향격리랍조（P＜0.05），저우덕흠조（P＜0.05）；수해발승고，CD3+、CD8+축점증고차상린량조간차이유통계학의의（P＜0.05）。결론：건강인군각항공능지표수해발승고유불동적개변，환만성고원병적위험성축점증가。
Objective:To investigate the CMS risk of healthy population in western Yunnan plateau. Methods:CMS risk of healthy population living at different districts was analyzed in 5 ways:bone density measurement, blood routine examination, hemorheological analysis, blood biochemistry and immunologic function. Results:The bone density of people gradually increased with elevation. RBC and Hb gradually increased and blood viscosity increased, the difference was statistically significant (P<0.05). Except for TP, Alb and Glu, other indexes of liver function increased with elevation. Indexes of renal function and myocardial enzymes increased as altitude rose(P<0.05). The TC, TG, LDL-C, APoB level of Dali and Weixi group were significantly lower than those of Shangri-La group(P<0.05), and these were even lower than Deqin group(P<0.05). The IgG, IgM, IgA, C3, C4 and CD3+, CD8+level of Dali and Weixi group were significantly lower than Shangri-La group (P<0.05), and were still lower than Deqin group (P<0.05). Conclusion:The indexes of bone density measurement, blood routine examination, hemorheological analysis, blood biochemistry and immunologic function of healthy people varied differently, and the CMS risk gradually increased.