CAJ | 학술논문

目的：观察曲美他嗪治疗慢性充血性心力衰竭(CHF)患者的临床疗效。方法选取2012年5月至2013年5月在我院就诊的CHF患者120例，按随机数表法分为观察组和对照组各60例。两组患者入院后均接受血管紧张素转化酶抑制剂(ACEI)、洋地黄、利尿剂、β受体阻滞剂等常规治疗，观察组在常规治疗基础上加用曲美他嗪，随访6个月后观察两组患者的治疗效果、心功能、6 min步行试验(6 mWT)等指标。结果经过6个月的治疗，观察组治疗总有效率、显效率均明显高于对照组，差异均有统计学意义(P<0.05)；治疗后，观察组左心室射血分数(LVEF)较对照组明显升高，心脏指数、6 mWT明显高于对照组，差异均有统计学意义(P<0.05)；观察者治疗后左心室舒张末期容积(LVDD)及左心室收缩末期容积(LVDS)均缩小，较对照组明显改善，血浆脑钠肽前体(PNT-proBNP)水平低于对照组，差异均有统计学意义(P<0.05)。结论在常规抗心衰治疗基础上使用曲美他嗪，可明显改善慢性充血性心力衰竭患者的左室功能，改善预后，提高生活质量。
목적：관찰곡미타진치료만성충혈성심력쇠갈(CHF)환자적림상료효。방법선취2012년5월지2013년5월재아원취진적CHF환자120례，안수궤수표법분위관찰조화대조조각60례。량조환자입원후균접수혈관긴장소전화매억제제(ACEI)、양지황、이뇨제、β수체조체제등상규치료，관찰조재상규치료기출상가용곡미타진，수방6개월후관찰량조환자적치료효과、심공능、6 min보행시험(6 mWT)등지표。결과경과6개월적치료，관찰조치료총유효솔、현효솔균명현고우대조조，차이균유통계학의의(P<0.05)；치료후，관찰조좌심실사혈분수(LVEF)교대조조명현승고，심장지수、6 mWT명현고우대조조，차이균유통계학의의(P<0.05)；관찰자치료후좌심실서장말기용적(LVDD)급좌심실수축말기용적(LVDS)균축소，교대조조명현개선，혈장뇌납태전체(PNT-proBNP)수평저우대조조，차이균유통계학의의(P<0.05)。결론재상규항심쇠치료기출상사용곡미타진，가명현개선만성충혈성심력쇠갈환자적좌실공능，개선예후，제고생활질량。
Objective To observe the clinical efficacy of trimetazidine for treating patients with chronic congestive heart failure (CHF). Methods A total of 120 patients with CHF treated in our hospital from May 2012 to May 2013 were divided into the observation group (n=60) and the control group (n=60) according to random num-ber table. The two groups of patients all accepted conventional treatment with angiotensin converting enzyme inhibi-tors (ACEI), digitalis, diuretics, beta-blockers. The observation group was additionally treated with trimetazidine. Af-ter a follow-up of 6 months, the clinical efficacy, heart function, indexes of 6 min walk test (6 mWT) were observed. Results After six months of treatment, the total effective rate, the marked effective rate in the observation group were significantly higher than those in the control group (P<0.05). After treatment, left ventricular ejection fraction (LVEF), cardiac index, 6 mWT in the observation group were significantly higher than those in the control group (P<0.05);the left ventricular end-diastolic dimension (LVDd) and left ventricular end-systolic dimension (LVDs) were sig-nificantly narrower;the level of plasma brain natriuretic peptide precursor (PNT-proBNP) was significantly lower (P<0.05). Conclusion Applying trimetazidine on the basis of conventional heart failure treatment can significantly im-prove left ventricular function in patients with CHF, and it can also improve prognosis and quality of life.