临床精神医学杂志
臨床精神醫學雜誌
림상정신의학잡지
JOURNAL OF CLINICAL PSYCHOLOGICAL MEDICINE
2015年
4期
221-223
,共3页
强迫症%艾司西酞普兰%氯米帕明%执行功能
彊迫癥%艾司西酞普蘭%氯米帕明%執行功能
강박증%애사서태보란%록미파명%집행공능
obsessive-compulsive disorder%escitalopram%clomipramine%executive function
目的：比较艾司西酞普兰与氯米帕明对强迫症患者执行功能障碍的影响。方法：将强迫症患者随机分为研究组（43例）和对照组（39例），分别给予艾司西酞普兰和氯米帕明治疗，疗程8周。分别于治疗前、治疗4及8周末进行耶鲁布朗强迫症量表（Y-BOCS）评估病情及疗效，同时进行连线测验（TMT）、彩色文字阅读测验（Stroop-C、Stroop-CW）评估患者的执行功能。结果：治疗4及8周后研究组 Y-BOCS 总分和强迫观念、强迫行为因子分均显著低于对照组（P ﹤0.05或 P ﹤0.01）；8周后 TMT-B[（46.2±8.6）s]、Stroop-C[（53.7±8.1）s]、Stroop-CW[（128.5±17.2）s]显著短于对照组[（51.3±7.4）s、（59.3±7.7）s、（136.9±16.5）s，P ﹤0.05或 P ﹤0.01]。结论：艾司西酞普兰对强迫症患者的疗效及执行功能的改善可能优于氯米帕明。
目的：比較艾司西酞普蘭與氯米帕明對彊迫癥患者執行功能障礙的影響。方法：將彊迫癥患者隨機分為研究組（43例）和對照組（39例），分彆給予艾司西酞普蘭和氯米帕明治療，療程8週。分彆于治療前、治療4及8週末進行耶魯佈朗彊迫癥量錶（Y-BOCS）評估病情及療效，同時進行連線測驗（TMT）、綵色文字閱讀測驗（Stroop-C、Stroop-CW）評估患者的執行功能。結果：治療4及8週後研究組 Y-BOCS 總分和彊迫觀唸、彊迫行為因子分均顯著低于對照組（P ﹤0.05或 P ﹤0.01）；8週後 TMT-B[（46.2±8.6）s]、Stroop-C[（53.7±8.1）s]、Stroop-CW[（128.5±17.2）s]顯著短于對照組[（51.3±7.4）s、（59.3±7.7）s、（136.9±16.5）s，P ﹤0.05或 P ﹤0.01]。結論：艾司西酞普蘭對彊迫癥患者的療效及執行功能的改善可能優于氯米帕明。
목적：비교애사서태보란여록미파명대강박증환자집행공능장애적영향。방법：장강박증환자수궤분위연구조（43례）화대조조（39례），분별급여애사서태보란화록미파명치료，료정8주。분별우치료전、치료4급8주말진행야로포랑강박증량표（Y-BOCS）평고병정급료효，동시진행련선측험（TMT）、채색문자열독측험（Stroop-C、Stroop-CW）평고환자적집행공능。결과：치료4급8주후연구조 Y-BOCS 총분화강박관념、강박행위인자분균현저저우대조조（P ﹤0.05혹 P ﹤0.01）；8주후 TMT-B[（46.2±8.6）s]、Stroop-C[（53.7±8.1）s]、Stroop-CW[（128.5±17.2）s]현저단우대조조[（51.3±7.4）s、（59.3±7.7）s、（136.9±16.5）s，P ﹤0.05혹 P ﹤0.01]。결론：애사서태보란대강박증환자적료효급집행공능적개선가능우우록미파명。
Objective:To compare the effects of escitalopram and clomipramine on executive functions in patients with obsessive-compulsive disorder(OCD). Method:Eighty-two OCD patients were randomly divid-ed into study group(43 cases,treated with escitalopram)and control group(39 cases treated with clomipra-mine). The period of treatment was 8 weeks. The illness of patients were assessed by Yale-Brown obsessive com-pulsive scale(Y-BOCS),and the executive functions were assessed by trail making test( TMT)-A and B, Stroop test(Stroop-C,Stroop-CW)before treatment,and at end of 4th,8th week after treatment,respectively. Results:In the study group,the total score of Y-BOCS and factors’scores of obsessive ideas and compulsive behavior after 4 and 8 weeks’treatment were significantly lower than those in the control one(P ﹤ 0. 05 or P ﹤0. 01). At the end of 8 weeks’treatment,the times of TMT-B[(46. 2 ± 8. 6)s],Stroop-C[(53. 7 ± 8. 1)s] and Stroop-CW[(128. 5 ± 17. 2)s ]in the study group were significantly shorter than those in the control [(51. 3 ± 7. 4)s,(59. 3 ± 7. 7)s,(136. 9 ± 16. 5)s](P ﹤ 0. 05 or P ﹤ 0. 01). Conclusion:Escitalopram has better curative effect and improvement of executive function than clomipramine in OCD patients.
