国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
16期
2414-2416
,共3页
脱落细胞学%肿瘤标志物%胸腔积液
脫落細胞學%腫瘤標誌物%胸腔積液
탈락세포학%종류표지물%흉강적액
exfoliative cytology%tumor marker%pleural effusion
目的：探讨脱落细胞学与肿瘤标志物癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、细胞角蛋白片段21-1(CYFRA21-1)、糖类抗原125(CA125)联合检查对胸腔积液鉴别诊断的临床价值。方法将216例胸腔积液患者依据明确诊断分为恶性组196例，良性组20例。除常规脱落细胞学检查外，采用电化学免疫发光技术检测胸腔积液中 CEA、CA19-9、CYFRA21-1、CA125等肿瘤标志物水平，并进行统计学分析。结果恶性组脱落细胞学检查阳性率82.7%，其中腺癌占87.7%。恶性组肿瘤标志物显著高于良性组，差异有统计学意义(P <0.05)，灵敏度分别为：CEA 52.0%、CA19-948.5%、CYFRA21-133.2%、CA12541.9%、四项肿瘤标志物74.5%。脱落细胞学与肿瘤标志物联合检查灵敏度96.4%、特异度80%、准确度96.8%。结论脱落细胞是确诊恶性胸腔积液的最好方法，肿瘤标志物则是较好的辅助诊断依据，脱落细胞与肿瘤标志物联合检查可提高良恶性胸腔积液鉴别诊断的灵敏度和准确度。
目的：探討脫落細胞學與腫瘤標誌物癌胚抗原(CEA)、糖類抗原19-9(CA19-9)、細胞角蛋白片段21-1(CYFRA21-1)、糖類抗原125(CA125)聯閤檢查對胸腔積液鑒彆診斷的臨床價值。方法將216例胸腔積液患者依據明確診斷分為噁性組196例，良性組20例。除常規脫落細胞學檢查外，採用電化學免疫髮光技術檢測胸腔積液中 CEA、CA19-9、CYFRA21-1、CA125等腫瘤標誌物水平，併進行統計學分析。結果噁性組脫落細胞學檢查暘性率82.7%，其中腺癌佔87.7%。噁性組腫瘤標誌物顯著高于良性組，差異有統計學意義(P <0.05)，靈敏度分彆為：CEA 52.0%、CA19-948.5%、CYFRA21-133.2%、CA12541.9%、四項腫瘤標誌物74.5%。脫落細胞學與腫瘤標誌物聯閤檢查靈敏度96.4%、特異度80%、準確度96.8%。結論脫落細胞是確診噁性胸腔積液的最好方法，腫瘤標誌物則是較好的輔助診斷依據，脫落細胞與腫瘤標誌物聯閤檢查可提高良噁性胸腔積液鑒彆診斷的靈敏度和準確度。
목적：탐토탈락세포학여종류표지물암배항원(CEA)、당류항원19-9(CA19-9)、세포각단백편단21-1(CYFRA21-1)、당류항원125(CA125)연합검사대흉강적액감별진단적림상개치。방법장216례흉강적액환자의거명학진단분위악성조196례，량성조20례。제상규탈락세포학검사외，채용전화학면역발광기술검측흉강적액중 CEA、CA19-9、CYFRA21-1、CA125등종류표지물수평，병진행통계학분석。결과악성조탈락세포학검사양성솔82.7%，기중선암점87.7%。악성조종류표지물현저고우량성조，차이유통계학의의(P <0.05)，령민도분별위：CEA 52.0%、CA19-948.5%、CYFRA21-133.2%、CA12541.9%、사항종류표지물74.5%。탈락세포학여종류표지물연합검사령민도96.4%、특이도80%、준학도96.8%。결론탈락세포시학진악성흉강적액적최호방법，종류표지물칙시교호적보조진단의거，탈락세포여종류표지물연합검사가제고량악성흉강적액감별진단적령민도화준학도。
Objective The paper discussed the clinical value of differential diagnosis of pleural effusion by combined examination of exfoliative cytology and tumor markers,such as Carcinoembryonic-antigen(CEA),Carbohydrate-antigen1 9-9 (CA1 9-9),Cytoker-antin-1 9-fragment 21-1 (CYFRA21-1)and carbohydrate antigen 125 (CA125).Methods A total of 21 6 patients with pleural effu-sion were divided into malignant group containing 1 96 patients and benign group consisting of remaining patients.Aside from the conventional exfoliative cytology examination,by electrochemical luminescence immunoassay technology,the contents of tumor markers of CEA,CA1 9-9,CYFRA21-1,CA125 in the pleural effusion were measured.Finally,the data were statistically analyzed. Results In malignant group,the positive rate of exfoliative cytologic examination was 82.7%,in which adenocarcinoma accounted for 87.7%.The tumor markers in malignant group was significantly higher than that of benign group.The difference was statisti-cally significant (P < 0.05 ).The sensitivity of CEA is 52.0%,CA1 9-9 48.5%,CA125 41.9%,and the four tumor markers is 74.5%,respectively.For the combined examination of exfoliative cytology and tumor marke,the sensitivity is 96.4%,and specifici-ty is 80%,accuracy is 96.8%.Conclusion The exfoliative cytologic examination is one of the best ways to diagnose malignant pleu-ral effusion.The tumor marker detection is a useful auxiliary method for correct diagnosis and treatment.The sensitivity and accura-cy of the diagnosis of benign and malignant pleural effusion can be improved by the exfoliative cytologic examination combined with tumor marker detection.
