CAJ | 학술논문

目的：探讨首次发病的精神分裂症患者感觉门控 P50特征及其相关临床因素。方法：给予87例首发未服药的精神分裂症住院患者（患者组）单一利培酮（4~6 mg/ d）治疗，疗程10周；治疗前后分别进行阳性和阴性综合征量表（PANSS）评定及 P50检测；以 PANSS 减分率50%分割点将患者分为有效组和无效组；P50检测结果与86名健康志愿者（对照组）比较；分析患者组 P50指标与临床因素的关系。结果：患者组治疗前 P50听觉条件（S1）、测试刺激（S2）潜伏期显著长于对照组，S1波幅及 S1-S2波幅差值显著低于对照组，S2/ S1显著高于对照组（P 均﹤0.01）；治疗后 S1、S2波幅较治疗前显著下降（P 均﹤0.01）；有效组与无效组间 P50各项指标差异无统计学意义；治疗前 S2波幅与 PANSS 阳性症状分呈正相关；S1-S2波幅差值与病程、PANSS 中一般精神病理分呈负相关；S2波幅/ S1波幅与病程、PANSS 总分及一般精神病理分正相关（P 均﹤0.05）。结论：首发精神分裂症患者 P50抑制缺陷；其与患者的病程、精神病理症状相关；利培酮治疗对 P50 S1、S2波幅有影响，但可能未改善其抑制缺陷。
목적：탐토수차발병적정신분렬증환자감각문공 P50특정급기상관림상인소。방법：급여87례수발미복약적정신분렬증주원환자（환자조）단일리배동（4~6 mg/ d）치료，료정10주；치료전후분별진행양성화음성종합정량표（PANSS）평정급 P50검측；이 PANSS 감분솔50%분할점장환자분위유효조화무효조；P50검측결과여86명건강지원자（대조조）비교；분석환자조 P50지표여림상인소적관계。결과：환자조치료전 P50은각조건（S1）、측시자격（S2）잠복기현저장우대조조，S1파폭급 S1-S2파폭차치현저저우대조조，S2/ S1현저고우대조조（P 균﹤0.01）；치료후 S1、S2파폭교치료전현저하강（P 균﹤0.01）；유효조여무효조간 P50각항지표차이무통계학의의；치료전 S2파폭여 PANSS 양성증상분정정상관；S1-S2파폭차치여병정、PANSS 중일반정신병리분정부상관；S2파폭/ S1파폭여병정、PANSS 총분급일반정신병리분정상관（P 균﹤0.05）。결론：수발정신분렬증환자 P50억제결함；기여환자적병정、정신병리증상상관；리배동치료대 P50 S1、S2파폭유영향，단가능미개선기억제결함。
Objective:To investigate the sensory gating P50 characteristics,its related factors and the effects of risperidone in first-episode patients with schizophrenia. Method:Eighty-seven first-episode untreat-ed patients with schizophrenia(case group)received single risperidone(4 - 6 mg/ d )for 10 weeks. Before and after treatment,the patients were assessed by positive and negative syndrome scale(PANSS)and detected by P50 respectively. With the segmentation point of 50% of PANSS reduction rate,the patients were divided into effective and ineffective groups. The results of P50 were compared with 86 healthy subjects(control group). The relationships were analyzed between the indicators of P50 and the clinical factors of the patients. Results:Compared to the control group,the incubation period of auditory conditions(S1)and the test stimulus(S2)in case group before treatment were significantly longer;the amplitudes of S1 and the difference of S1-S2 were sig-nificantly lower;the amplitude S2 / S1 was significantly higher(all P ﹤ 0. 01). After treatment,the amplitudes of S1,S2 were significant lower than before treatment(all P ﹤ 0. 01). The indicators of P50 between the effective and ineffective groups showed no significant difference. In case group before treatment S2 amplitude was posi-tively correlated with PANSS positive symptoms score;the value of S1-S2 was negatively correlated with course and PANSS general mental pathological score;S2 / S1 was positively correlated with course,total score of PANSS and general mental pathological score(all P ﹤ 0. 05). Conclusion:There are sensory gating deficits associat-ed in first-episode untreated patients with schizophrenia;which is correlated with the course and mental patho-logical symptoms of the patients. Risperidone can affect the amplitudes of S1,S2 of P50,but can not improve its inhibition of defects of the patients.