CAJ | 학술논문

目的：通过分析对比丙氨酸氨基转移酶(ALT)临界值调整后40~50 U/L 和大于50 U/L 献血者的血液检测结果,观察降低血液报废率效果和探讨 ALT 异常与 HBV 和 HCV 感染的相关性。方法分析青岛市中心血站2013~2014年2656例ALT>40 U/L 的无偿献血者的 HBV 和 HCV 血清学和核酸检测(NAT)结果并进行相关性研究。结果ALT 在40~50 U/L 者共1771例(66.68%),其中6例 HBsAg ELISA(+),NAT(+)2例,NAT(-)4例,8例抗-HCV 抗体 ELISA(+)样本中,NAT (+)4例,NAT(-)3例,1例 TP 阳性未做 NAT。ALT>50 U/L 的885例献血者中,HBsAg 反应性者5例,抗-HCV 抗体反应性者7例,全无反应性者873例。相关性统计数据表明：ALT 与 HBV 差异无统计学意义(P <0.05),ALT 与 HCV 差异有统计学意义(P >0.05)。结论ALT 在40~50 U/L 的献血者的比例远远高于50 U/L 以上的献血者,调整临界值后大大降低了血液报废率,ALT 升高与 HBV 发生存在相关性而与 HCV 的发生不存在相关性。
목적：통과분석대비병안산안기전이매(ALT)림계치조정후40~50 U/L 화대우50 U/L 헌혈자적혈액검측결과,관찰강저혈액보폐솔효과화탐토 ALT 이상여 HBV 화 HCV 감염적상관성。방법분석청도시중심혈참2013~2014년2656례ALT>40 U/L 적무상헌혈자적 HBV 화 HCV 혈청학화핵산검측(NAT)결과병진행상관성연구。결과ALT 재40~50 U/L 자공1771례(66.68%),기중6례 HBsAg ELISA(+),NAT(+)2례,NAT(-)4례,8례항-HCV 항체 ELISA(+)양본중,NAT (+)4례,NAT(-)3례,1례 TP 양성미주 NAT。ALT>50 U/L 적885례헌혈자중,HBsAg 반응성자5례,항-HCV 항체반응성자7례,전무반응성자873례。상관성통계수거표명：ALT 여 HBV 차이무통계학의의(P <0.05),ALT 여 HCV 차이유통계학의의(P >0.05)。결론ALT 재40~50 U/L 적헌혈자적비례원원고우50 U/L 이상적헌혈자,조정림계치후대대강저료혈액보폐솔,ALT 승고여 HBV 발생존재상관성이여 HCV 적발생불존재상관성。
Objective To analyze the blood screening results after adjustment of critical value 40 to 50 U/L and to observe the effect of reducing blood scrap rate and to discuss the correlation between ALT and HBV,HCV infection.Methods We screened 2656 blood donors (ALT >40 U/L)by serological and nucleic acid amplification testing(NAT)in Qingdao blood center from 2013 to 2014,and conducted the correlation analysis by chi square test.Results 1 771 cases (66.68%)were ALT 40-50 U/L,including 6 cases of HBsAg ELISA (+),2 cases NAT (+),4 cases NAT(-).In the 8 cases of anti-HCV ELISA (+)samples,4 cases NAT (+),3 cases NAT (-),1 case with positive TP without NAT result.In 885 blood donors with ALT>50 U/L,5 cases were HBsAg-reactive,7 cases were anti-HCV-reactive,and 873 cases were negative.Related statistics showed that there was no signifi-cant difference between ALT and HBV infection (P <0.05),but significant difference was found between ALT and HCV infection (P >0.05).Conclusion The proportion of blood donors with ALT 40-50 U/L is much higher than that with ALT >50 U/L do-nors.Adjustment of the critical value greatly reduces blood scrap rate.Elevated ALT is associated with the infection of HBV but not with HCV.