CAJ | 학술논문

目的：探讨血清新喋呤(Npt)在肾炎患者病程中的表达及新喋呤与急、慢性肾炎的预后关系。方法对40例急性肾炎患者(A1组)和30例慢性肾炎患者(A2组)按病期采血,分别用酶联免疫吸附试验(ELISA)检测 Npt 的水平,用日立全自动生化分析仪检测血清肌酐(Cr)和尿素氮(BUN)的水平。另取50例健康献血者(B 组)作为对照组(B 组)。结果A1、A2组血清Npt 浓度明显高于 B 组(P <0.05),A1、A2组之间 Npt 水平也有差异(P <0.05),且 A1组、A2组与 B 组比较,Cr 和 BUN 明显增高,差异有统计学意义(P <0.05)。结论血清 Npt 是肾炎患者病情进展及早期诊断的敏感指标,对疾病的诊断及疗效监测有一定的临床价值。
목적：탐토혈청신첩령(Npt)재신염환자병정중적표체급신첩령여급、만성신염적예후관계。방법대40례급성신염환자(A1조)화30례만성신염환자(A2조)안병기채혈,분별용매련면역흡부시험(ELISA)검측 Npt 적수평,용일립전자동생화분석의검측혈청기항(Cr)화뇨소담(BUN)적수평。령취50례건강헌혈자(B 조)작위대조조(B 조)。결과A1、A2조혈청Npt 농도명현고우 B 조(P <0.05),A1、A2조지간 Npt 수평야유차이(P <0.05),차 A1조、A2조여 B 조비교,Cr 화 BUN 명현증고,차이유통계학의의(P <0.05)。결론혈청 Npt 시신염환자병정진전급조기진단적민감지표,대질병적진단급료효감측유일정적림상개치。
Objective To evaluate the expression of serum neopterin in nephritic patients and its relationship with the prognosis of acute and chronic nephritis.Methods The levels of serum neopterin were determined in 40 patients with acute nephritis (A1 group)and 30 patients with chronic nephritis (A2 group)by enzyme-linked immunosorbent assay.The contents of serum creatinine and blood urea nitrogen were determined by Hitachi fully automatic biochemical analyzer.50 healthy blood donors were in the con-trol group.Results The levels of serum neopterin in acute nephritis and chronic nephritis were significantly higher than that in the normal group(P <0.05).The levels of serum neopterin in acute nephritis were significantly higher than that in chronic nephritis(P<0.05).The levels of serum creatinine and blood urea nitrogen in two nephritis group were significantly higher than that in the normal group(P <0.05).Conclusion The measurement of the serum neopterin may be a useful sensitive index for early diagnosis. This may be helpful for diagnosis and evaluation of therapy effect.