CAJ | 학술논문

目的：系统评价纤维蛋白原联合 D-二聚体在肺栓塞诊断中的临床价值。方法计算机检索 PubMed(1966~2014.7)、Embase(1980~2014.7)、Web of science(1980~2014.7)、中国生物医学文献数据库(CBM,1978~2014.7)、中国知网(CNKI,1979~2014.7)、维普数据库(VIP,1989~2014.7)、万方数据库(WF,1982~2014.7)。收集用纤维蛋白原联合 D-二聚体诊断肺栓塞的试验研究,依据 QUADAS 质量评价标准评价纳入研究的质量后,采用 Meta-Disc 软件(version1.4)进行 Meta 分析。结果最终纳入8篇研究。合计1015例受试者。Meta 分析结果显示：纤维蛋白原联合 D-二聚体诊断肺栓塞的合并特异度、灵敏度、阴性似然比、阳性似然比、诊断比值比和 ROC 曲线下面积分别0.63(0.58,0.67),0.90(0.87,0.92),0.14(0.07,0.27),2.35(1.91,2.88),18.99(12.08,29.85),0.8597。结论纤维蛋白原联合 D-二聚体在肺栓塞诊断中具有中等特异度和较高的灵敏度,可作为临床筛查肺栓塞患者的有效措施之一。
목적：계통평개섬유단백원연합 D-이취체재폐전새진단중적림상개치。방법계산궤검색 PubMed(1966~2014.7)、Embase(1980~2014.7)、Web of science(1980~2014.7)、중국생물의학문헌수거고(CBM,1978~2014.7)、중국지망(CNKI,1979~2014.7)、유보수거고(VIP,1989~2014.7)、만방수거고(WF,1982~2014.7)。수집용섬유단백원연합 D-이취체진단폐전새적시험연구,의거 QUADAS 질량평개표준평개납입연구적질량후,채용 Meta-Disc 연건(version1.4)진행 Meta 분석。결과최종납입8편연구。합계1015례수시자。Meta 분석결과현시：섬유단백원연합 D-이취체진단폐전새적합병특이도、령민도、음성사연비、양성사연비、진단비치비화 ROC 곡선하면적분별0.63(0.58,0.67),0.90(0.87,0.92),0.14(0.07,0.27),2.35(1.91,2.88),18.99(12.08,29.85),0.8597。결론섬유단백원연합 D-이취체재폐전새진단중구유중등특이도화교고적령민도,가작위림상사사폐전새환자적유효조시지일。
Objective To systemically evaluate the accuracy of fibrinogen(FIB)and D-dimer testing for diagnosing pulmonary embolism(PE).Methods Systematic and comprehensive literature was searched in PubMed(1 966 to July 2014),Embase(1 980 to July 2014),Web of science(1 980 to July 2014),CBM(1 978 to July 2014),CNKI(1 979 to July 2014),VIP(1 989 to July 2014),WF (1 982 to July 2014).The relative studies of FIB and D-dimer for PE were included.The quality assessment of diagnostic accuracy studies(QUADAS)items were used to assess the quality of the included studies.The Meta-Disc(version 1.4)software was used to analyze the data.Results A total of 8 studies were included.The results of Meta-analyses showed the pooled specificity,sensitivity, negative likelihood ratio,positive likelihood ratio,ROC value,and summary receiver operating characteristic curve of FIB and D-di-mer were 0.63(0.58,0.67),0.90(0.87,0.92),0.14(0.07,0.27),2.35 (1.91,2.88),18.99(12.08,29.85),0.859 7 respectively. Conclusion The FIB and D-dimer has a moderate specificity and higher sensitivity in the diagnosis of PE,which could be used as one of selecting tests of PE.