CAJ | 학술논문

目的：研究体外冲击波碎石术(SWL)治疗的渝东南地区尿路结石患者碎石前后生化指标的变化，结合尿路结石成分分析，为渝东南地区尿路结石患者行 SWL 治疗提供依据。方法对该院2008~2014年 SWL 治疗的328例尿路结石患者碎石前后尿微量清蛋白(mAlb)，血清β2-微球蛋白(β2-MG)、尿素氮(BUN)、肌酐(Cr)的检测，并进行统计学分析，同时对排出体外的碎石成分进行分析。结果患者β2-MG 及尿 mAlb 治疗后第1~2天显著升高，第2天达峰值，治疗前、后比较差异有统计学意义(P <0.05)，第4、7天有所下降，但治疗前、后比较差异有统计学意义(P <0.05)，第10天恢复至正常水平，与治疗前差异无统计学意义(P >0.05)；治疗后 BUN 及 Cr 虽略有升高，但与治疗前差异无统计学意义(P >0.05)。结论对 SWL 治疗的尿路结石患者进行治疗前、后血清β2-MG、尿 mAlb 的检测及结石成分分析，有助于对渝东南地区尿路结石患者的 SWL 治疗方法提供指导作用。
목적：연구체외충격파쇄석술(SWL)치료적투동남지구뇨로결석환자쇄석전후생화지표적변화，결합뇨로결석성분분석，위투동남지구뇨로결석환자행 SWL 치료제공의거。방법대해원2008~2014년 SWL 치료적328례뇨로결석환자쇄석전후뇨미량청단백(mAlb)，혈청β2-미구단백(β2-MG)、뇨소담(BUN)、기항(Cr)적검측，병진행통계학분석，동시대배출체외적쇄석성분진행분석。결과환자β2-MG 급뇨 mAlb 치료후제1~2천현저승고，제2천체봉치，치료전、후비교차이유통계학의의(P <0.05)，제4、7천유소하강，단치료전、후비교차이유통계학의의(P <0.05)，제10천회복지정상수평，여치료전차이무통계학의의(P >0.05)；치료후 BUN 급 Cr 수략유승고，단여치료전차이무통계학의의(P >0.05)。결론대 SWL 치료적뇨로결석환자진행치료전、후혈청β2-MG、뇨 mAlb 적검측급결석성분분석，유조우대투동남지구뇨로결석환자적 SWL 치료방법제공지도작용。
Objective To study the change of kidney injury biochemical index before and after SWL in southeast of Chongqing, and toanalyze the constituents of urinary stones,thus to provide the evidence for the treatment of patients with urinary stones by SWL in southeast of Chongqing.Methods 328 patients with urinary stones form our hospital in Southeast of Chongqing during 2008 to 2014 underwent SWL were enrolled.And we detected the levels of urine mALB,serum β2-MG,BUN,Cr before and after operation.The results were statistically analyzed.The chemical constituents of stones were analyzed.Results The levels of urine mALB,serumβ2-MG obviously increased on day 1-2 after operation,and reached the peak 2 days after operation.The result after 1-2 days showed significant difference(P <0.01).The levels returned to normal after 10 days.Compared with the levels before operation,the results after 10 days showed no significant difference(P >0.05).Compared with the levels before operation,the levels of BUN and Cr slightly increased,with no significant difference(P >0.05).Conclusion The detection of urine mALB,serum β2-MG of patients with urinary stones before and after SWL and analysis of the chemical compositions of urinary stones could provide the evidence for the treatment of patients with urinary stones by SWL in Southeast of Chongqing.