CAJ | 학술논문

目的：探究先天性肾积水患儿血清中的血清胱抑素 C(CysC)、β2-微球蛋白(β2-MG)、α1-微球蛋白(α1-MG)的表达及在疾病中的诊断意义。方法选择该院小儿外科及泌尿外科收治的经过彩超诊断为先天性肾积水的患儿98例。收集患儿标本后，将患有肾积水的患儿设为 B 组，另外有98例体检健康的小儿设为 A 组，作为对照。然后采用酶联免疫吸附试验检测该2组患儿血清中的 Cys C、β2-MG 及α1-MG 水平，将数据进行整理分析。结果肾积水程度与患儿血清中 CysC、β2-MG 及α1-MG 表达水平呈正相关，程度越重，表达水平越高。与对照组比较，不同程度的肾积水患儿血清中 CysC、β2-MG 及α1-MG 表达水平差异均有统计学意义(P >0.05)。结论CysC、β2-MG 及α1-MG 可作为评价肾积水、肾功能损害的常规检测指标之一，对于肾功能检测与诊断具有重要意义。
목적：탐구선천성신적수환인혈청중적혈청광억소 C(CysC)、β2-미구단백(β2-MG)、α1-미구단백(α1-MG)적표체급재질병중적진단의의。방법선택해원소인외과급비뇨외과수치적경과채초진단위선천성신적수적환인98례。수집환인표본후，장환유신적수적환인설위 B 조，령외유98례체검건강적소인설위 A 조，작위대조。연후채용매련면역흡부시험검측해2조환인혈청중적 Cys C、β2-MG 급α1-MG 수평，장수거진행정리분석。결과신적수정도여환인혈청중 CysC、β2-MG 급α1-MG 표체수평정정상관，정도월중，표체수평월고。여대조조비교，불동정도적신적수환인혈청중 CysC、β2-MG 급α1-MG 표체수평차이균유통계학의의(P >0.05)。결론CysC、β2-MG 급α1-MG 가작위평개신적수、신공능손해적상규검측지표지일，대우신공능검측여진단구유중요의의。
Objective To explore the expression level and the clinical significance of Cys C,β2-MG,α1-MG in pediatric patients with congenital hydronephrosis.Methods 98 pediatric patients definitely diagnosed with congenital hydronephrosis in the depart-ment of pediatric surgery and urology of our hospital were enrolled and assigned to group B.The blood samples were collected.Ad-ditionally,selected another 98 normal children as a control:group A.Then the expression level of Cys C,β2-MG andα1-MG were de-tected via ELLSA for the groups.Results With aggravation of hydronephrosis,the expression of Cys C,β2-MG andα1-MG elevated correspondingly.Moreover,compared to the control group,the expression of Cys C,β2-MG andα1-MG in the pediatric patients with different degrees had significant differences(P <0.05),After the nephropyeloplasty,the expression of Cys C,β2-MG andα1-MG de-creased respectively.Compared to the pre-operation,it had significant difference(P <0.05),but no statistical significance compared with the control(P >0.05).Conclusion Cys C,β2-MG and α1-MG can be used for evaluating the hydronephrosis and renal impair-ment.And it has more important significance by combining them.