CAJ | 학술논문

目的：探讨血清缺血修饰清蛋白(IMA)、心型脂肪酸结合蛋白(H-FABP)、B 型利钠肽(BNP)、同型半胱氨酸(Hcy)与不稳定性心绞痛(UA)危险分层的关联性,为临床提供评估患者病情的依据。方法选取135例不稳定性心绞痛(UA)患者作为病例组,根据全球急性冠状动脉事件注册(GRACE)危险评分软件,将病例组分为低危组70例、中危组60例及高危组5例；另选取体检健康者145例作为对照组。检测血清 IMA、H-FABP、BNP 及 Hcy 水平,将病例组与对照组、病例组各危险分层进行比较。结果将病例组与对照组比较,血清 H-FABP、BNP 及 Hcy 水平差异具有统计学意义(P <0.05),血清 IMA 差异无统计学意义(P >0.05)；病例组内各危险分层 IMA、H-FABP、Hcy 水平差异均无统计学意义(P >0.05)；高危组 BNP 水平高于低危组和中危组,差异有统计学意义(P <0.05),中危组与低危组比较差异无统计学意义(P >0.05)。结论H-FABP、BNP 及 Hcy 对临床诊断 UA 有一定意义,BNP 对患者病情危险程度有提示作用。
목적：탐토혈청결혈수식청단백(IMA)、심형지방산결합단백(H-FABP)、B 형리납태(BNP)、동형반광안산(Hcy)여불은정성심교통(UA)위험분층적관련성,위림상제공평고환자병정적의거。방법선취135례불은정성심교통(UA)환자작위병례조,근거전구급성관상동맥사건주책(GRACE)위험평분연건,장병례조분위저위조70례、중위조60례급고위조5례；령선취체검건강자145례작위대조조。검측혈청 IMA、H-FABP、BNP 급 Hcy 수평,장병례조여대조조、병례조각위험분층진행비교。결과장병례조여대조조비교,혈청 H-FABP、BNP 급 Hcy 수평차이구유통계학의의(P <0.05),혈청 IMA 차이무통계학의의(P >0.05)；병례조내각위험분층 IMA、H-FABP、Hcy 수평차이균무통계학의의(P >0.05)；고위조 BNP 수평고우저위조화중위조,차이유통계학의의(P <0.05),중위조여저위조비교차이무통계학의의(P >0.05)。결론H-FABP、BNP 급 Hcy 대림상진단 UA 유일정의의,BNP 대환자병정위험정도유제시작용。
Objective To determine the value of ischemia modified albumin,heart-type fatty acid-binding protein,B-type natri-uretic peptide and homocysteine in the risk stratification of patients with unstable angina pectoris;thus to provide an assessment for the condition of patients in clinic.Methods 135 patients with unstable angina were included in the disease group and subjected to risk stratification according to GRACE risk score software,70 cases of low-risk group,60 cases in the middle-risk group and 5 cases in the high-risk group.Another 145 healthy people were in the control group.The levels of ischemia modified albumin,heart-type fatty acid-binding protein,B-type natriuretic peptide and homocysteine were detected and compared.Results Between the control group and the disease group,significant difference of heart-type fatty acid-binding protein,B-type natriuretic peptide and homocys-teine was found (P <0.05),but the difference of ischemia modified albumin was not statistically significant(P >0.05).In the dis-ease group,the levels of ischemia modified albumin,heart-type fatty acid-binding protein and homocysteine in each risk stratification showed no significant difference(P >0.05).The level of B-type natriuretic peptide in high-risk group was higher than that in the low-risk group and in the middle-risk group and the difference was statistically significant (P <0.05),while there was no statisti-cally significant difference between the low-risk group and the middle-risk group(P >0.05 ).Conclusion The detection of heart-type fatty acid-binding protein,B-type natriuretic peptide and homocysteine possesses certain meaning in diagnosing unstable angi-na,and the level of B-type natriuretic peptide indicates the risk degree of the disease.