中华口腔医学研究杂志（电子版）
中華口腔醫學研究雜誌（電子版）
중화구강의학연구잡지（전자판）
CHINESE JOURNAL OF STOMATOLOGICAL RESEARCH(ELECTRONIC VERSION)
2015年
4期
333-336
,共4页
牙本质粘接%生物降解%基质金属蛋白酶%酶抑制剂%耐久性
牙本質粘接%生物降解%基質金屬蛋白酶%酶抑製劑%耐久性
아본질점접%생물강해%기질금속단백매%매억제제%내구성
Dentin adhesive%Biodegradation%Matrix metalloproteinases%Enzyme inhibitor%Durability
随着牙本质粘接技术的不断发展,粘接效果也得到很大提高,但树脂牙本质粘接界面仍然受到诸多因素的影响。有研究表明,牙本质粘接剂中的亲水性和酸性单体可使粘接混合层具有较强的吸水性,容易引起聚合物的水解。同时,混合层内的不稳定聚合物可使胶原纤维受到侵蚀从而变得脆弱,容易被宿主源性的基质金属蛋白酶(MMP)降解。因此,MMP在降解Ι型胶原的过程中发挥着重要作用,从而影响牙本质的粘接耐久性。本文就MMP介导的树脂牙本质粘接界面生物降解机理及其拮抗剂的应用做一简要综述。
隨著牙本質粘接技術的不斷髮展,粘接效果也得到很大提高,但樹脂牙本質粘接界麵仍然受到諸多因素的影響。有研究錶明,牙本質粘接劑中的親水性和痠性單體可使粘接混閤層具有較彊的吸水性,容易引起聚閤物的水解。同時,混閤層內的不穩定聚閤物可使膠原纖維受到侵蝕從而變得脆弱,容易被宿主源性的基質金屬蛋白酶(MMP)降解。因此,MMP在降解Ι型膠原的過程中髮揮著重要作用,從而影響牙本質的粘接耐久性。本文就MMP介導的樹脂牙本質粘接界麵生物降解機理及其拮抗劑的應用做一簡要綜述。
수착아본질점접기술적불단발전,점접효과야득도흔대제고,단수지아본질점접계면잉연수도제다인소적영향。유연구표명,아본질점접제중적친수성화산성단체가사점접혼합층구유교강적흡수성,용역인기취합물적수해。동시,혼합층내적불은정취합물가사효원섬유수도침식종이변득취약,용역피숙주원성적기질금속단백매(MMP)강해。인차,MMP재강해Ι형효원적과정중발휘착중요작용,종이영향아본질적점접내구성。본문취MMP개도적수지아본질점접계면생물강해궤리급기길항제적응용주일간요종술。
With the continuous development of dentin adhesive technology, adhesive effect has also been greatly improved, but the adhesive interface is still affected by many factors. The hydrophilic and acidic monomers of current dentin adhesives have made hybrid layer highly prone to water sorption. This, in turn, causes polymer degradation. These unstable polymers inside the hybrid layer may result in denuded collagen fibers, which become vulnerable to mechanical and hydrolytical fatigue, as well as degradation by host-derived the matrix metalloproteinases (MMPs) with collagenolytic activity. Therefore, MMPs have a crucial role in the degradation of typeΙcollagen, thus affecting the durability of the dentin adhesive. The purpose of this review is to summarize the progress on the biodegraded mechanism of resin-dentin adhesive interface mediated by MMPs and the application of its antagonists.
