CAJ | 학술논문

目的：评价补肾固齿丸在牙周炎治疗中的疗效及安全性。方法电子检索中国生物医学文献数据库(CBM,1978年1月至2015年4月)、Medline(1950年1月至2015年4月)、Cochrane图书馆临床随机对照试验库(CENTRAL,2015年第4期),收集有关补肾固齿丸治疗牙周炎的临床随机对照试验与临床对照试验。两位研究者采用CONSORT质量评价标准对文献进行质量评价并提取其关于临床有效率、牙周探诊深度(PD)和牙槽骨平均灰度值的数据后,采用Revman 5.3.5进行Meta分析。结果最终纳入8篇文献,共498例患者。 Meta分析显示,补肾固齿丸能有效缓解牙周炎患者的症状(OR =3.98,95% CI=[2.23,7.10],P﹤0.05),明显降低PD(WMD=-0.75,95%CI=[-1.42,-0.09],P=0.03),但在促进牙周骨组织再生方面,差异无统计学意义(WMD=1.79,95%CI=[-0.38,3.95],P=0.11)。结论补肾固齿丸对牙周炎有显著的治疗作用,值得在临床上推广。
목적：평개보신고치환재아주염치료중적료효급안전성。방법전자검색중국생물의학문헌수거고(CBM,1978년1월지2015년4월)、Medline(1950년1월지2015년4월)、Cochrane도서관림상수궤대조시험고(CENTRAL,2015년제4기),수집유관보신고치환치료아주염적림상수궤대조시험여림상대조시험。량위연구자채용CONSORT질량평개표준대문헌진행질량평개병제취기관우림상유효솔、아주탐진심도(PD)화아조골평균회도치적수거후,채용Revman 5.3.5진행Meta분석。결과최종납입8편문헌,공498례환자。 Meta분석현시,보신고치환능유효완해아주염환자적증상(OR =3.98,95% CI=[2.23,7.10],P﹤0.05),명현강저PD(WMD=-0.75,95%CI=[-1.42,-0.09],P=0.03),단재촉진아주골조직재생방면,차이무통계학의의(WMD=1.79,95%CI=[-0.38,3.95],P=0.11)。결론보신고치환대아주염유현저적치료작용,치득재림상상추엄。
Objective To assess the effect and safety of Bushenguchiwan on the treatment of periodontitis. Methods The electronic search was conducted in CBM (1978 Jan-2015 Apr), Medline (OVID, 1950 Jan-2015 Apr), and CENTRAL (2015, Issue 4). The clinical randomized controlled trials and clinical controlled trials involved the topic were selected. Two investigators evaluated the quality of the included trials with CONSORT statement and the data about clinical efficacy rate, periodontal probing depth and mean grey values were collected for Meta analysis with Revman 5.3.5. Results Eight publications met the inclusion criteria and 498 patients were involved. Meta analysis showed Bushenguchiwan significantly relieved the symptoms of periodontitis (OR=3.98, 95% CI=[2.23,7.10], P﹤0.05), and decreased probing depth (PD) (WMD = -0.75, 95% CI = [-1.42,-0.09], P= 0.03), without promoting bone regeneration (WMD=1.79, 95% CI=[-0.38,3.95], P=0.11). Conclusion Bushenguchiwan is effective on the treatment of periodontitis and is worth being promoted.